CAJ | 학술논문

Janus激酶/信号转导与转录激活子（JAK/STAT）是一条依靠多种细胞因子和生长因子共同介导的信号通路，广泛参与了细胞的增殖、分化、凋亡及免疫调节等病理生理过程。多项研究表明，JAK/STAT信号通路对机体不同的组织及器官如肾脏、肝脏、肺、心脏等的纤维化形成过程具有重要的调控作用。该文就近年JAK/STAT信号通路与机体组织器官纤维化形成的相关性研究作一综述。
Janus격매/신호전도여전록격활자（JAK/STAT）시일조의고다충세포인자화생장인자공동개도적신호통로，엄범삼여료세포적증식、분화、조망급면역조절등병리생리과정。다항연구표명，JAK/STAT신호통로대궤체불동적조직급기관여신장、간장、폐、심장등적섬유화형성과정구유중요적조공작용。해문취근년JAK/STAT신호통로여궤체조직기관섬유화형성적상관성연구작일종술。
The JAK/STAT signal pathway is collectively mediated by a variety of cytokines and growth factors,and is extensively involved in cell proliferation,differentiation,apoptosis,immunoregulation and other pathophysiological processes. Many studies demonstrate that JAK/STAT pathway plays an important role in regulating the fibrosis process of different tissues and organs,such as kidney,liver,lung and heart.This study reviewed the correlation between the JAK/STAT signal transduction pathway and the process of tis-sue and organ fibrosis.