CAJ | 학술논문

目的：探讨扩张型心肌病心力衰竭患者应用曲美他嗪治疗的临床效果。方法：选取80例扩张型心肌病患者为本次研究对象，随机将其分为对照组与观察组各40例，两组患者均服用β-受体阻滞剂、利尿药、洋地黄以及血管紧张素转换酶抑制剂等常规药物治疗；观察组患者则在此基础上接受曲美他嗪药物治疗，疗程为3个月。治疗结束后对两组患者心功能、左室射血分数（LVEF）、左室舒张末期内径（LVEDD）和左室收缩末期内径（LVESD）变化进行观察和对比。结果：与对照组相比，观察组心功能改善者显著更高（P <0.05）；与治疗前相比，观察组患者LVEF 值明显提高，左室舒张、收缩末期内径明显缩小（ P <0.05）。结论：对于扩张型心肌患者群来说，曲美他嗪有利于其心功能的改善，并能够逆转心室重构，疗效确切，值得临床推广应用。
목적：탐토확장형심기병심력쇠갈환자응용곡미타진치료적림상효과。방법：선취80례확장형심기병환자위본차연구대상，수궤장기분위대조조여관찰조각40례，량조환자균복용β-수체조체제、이뇨약、양지황이급혈관긴장소전환매억제제등상규약물치료；관찰조환자칙재차기출상접수곡미타진약물치료，료정위3개월。치료결속후대량조환자심공능、좌실사혈분수（LVEF）、좌실서장말기내경（LVEDD）화좌실수축말기내경（LVESD）변화진행관찰화대비。결과：여대조조상비，관찰조심공능개선자현저경고（P <0.05）；여치료전상비，관찰조환자LVEF 치명현제고，좌실서장、수축말기내경명현축소（ P <0.05）。결론：대우확장형심기환자군래설，곡미타진유리우기심공능적개선，병능구역전심실중구，료효학절，치득림상추엄응용。
Objective To explore dilated cardionyopathy heart failure patients treated with trinetazidine therapy clinical re-sults. Method 80 patients with dilated cardionyopathy patients were randonly divided into two groups:the control group(n=40)and the observation group(n=40),the patients in two groups were taking β- blockers,diuretics,digitalis and angiotensin converting enzyne in-hibitors and other conventional drug treatnent;the patients in the observation group were treated with trinetazidine for three nonths. After treatnent of the two groups of cardiac function in patients,left ventricular ejection fraction( LVEF),left ventricular end-diastolic dianeter ( LVEDD)and left ventricular end systolic dianeter( LVESD)changes were observed and conpared. Results Conpared with the control group,cardiac function in the observation group was inproved significantly(P<0. 05);conpared with before treatnent,LVEF of patients in the observation group was significantly increased,left ventricular diastolic and systolic dianeter were significantly reduced( P <0. 05 ) . Conclusion For patients with dilated cardionyopathy group,the trinetazidine is beneficial to the inprovenent of cardiac function and able to reverse ventricular renodeling,efficacy,it is worthy of clinical application.