CAJ | 학술논문

目的：对细菌溶解产物防治小儿反复呼吸道感染（RRTI）患者急性呼吸道感染的效果进行荟萃分析。方法：以接受免疫刺激剂治疗的 RRTI 患者作为研究对象，通过荟萃分析得到的患者 RRTI 发作次数作为效果指标，时间检索范围为2000年1月1日至2013年11月10日。结果：共检索到128篇文献，其中19项研究满足本研究的纳入标准，共959名患者。荟萃分析显示，在常规治疗基础上加用细菌溶解产物制剂，能显著减少 RRTI 患者急性呼吸道感染的发作次数，敏感性分析显示结果稳健。与单用常规治疗的患者相比，12个月内，加用细菌溶解产物的患者平均减少了2．963次急性呼吸道感染。结论：对 RRTI 患者，在治疗中使用细菌溶解产物能改善患者健康，降低患者发病风险。
목적：대세균용해산물방치소인반복호흡도감염（RRTI）환자급성호흡도감염적효과진행회췌분석。방법：이접수면역자격제치료적 RRTI 환자작위연구대상，통과회췌분석득도적환자 RRTI 발작차수작위효과지표，시간검색범위위2000년1월1일지2013년11월10일。결과：공검색도128편문헌，기중19항연구만족본연구적납입표준，공959명환자。회췌분석현시，재상규치료기출상가용세균용해산물제제，능현저감소 RRTI 환자급성호흡도감염적발작차수，민감성분석현시결과은건。여단용상규치료적환자상비，12개월내，가용세균용해산물적환자평균감소료2．963차급성호흡도감염。결론：대 RRTI 환자，재치료중사용세균용해산물능개선환자건강，강저환자발병풍험。
Objective:The use of bacterial lysates as an immune-modulator to boost immunological response in patients with recurrent respiratory tract infections (RRTI)and its effects on the attack frequency of respiratory infection have been widely debated.We aimed to conduct our Meta-analysis on the effect of bacterial lysates plus routine care versus routine care only on the attack frequency of respiratory infection in patients with RRTI.Methods: We performed a systematic review of articles published from January 1,2000 to November 10, 2013.We included all randomized trials that compared outcomes between patients with RRTI receiving bacterial lysates plus routine care with those receiving routine care only.Eligible studies, determined by consensus with predefined criteria,were reviewed and data were ex-tracted onto a standard form.We combined data to assess the primary outcome of attack frequency of respiratory infection using the DerSi-monian and Laird random effects model.Results: Our search identified 128 reports,of which 19 studies met our inclusion criteria and were included in our Meta-analysis.Analysis of the 19 randomized trials(959 patients) that reported an outcome on the attack frequency of respiratory infection showed that patients assigned to bacterial lysates plus routine care had a 2.963 reduction in respiratory tract infections compared to those assigned to routine care only.Conclusion: Bacterial lysates are associated with a decreased risk of respiratory tract in-fections in patients with RRTI.