CAJ | 학술논문

婴儿黑色素神经外胚瘤（MNTI）是一种少见的、增长迅速的神经脊来源良性肿瘤，多发生于1岁以内婴幼儿。好发部位为上颌骨前部，下颌骨的病例少见。本文报道1例发生于下颌骨并行手术治疗的MNTI病例，并通过文献回顾探讨MNTI的病例特点及诊断治疗要点。口腔婴儿MNTI具有典型的发病部位与发病年龄，临床检查时应注意肿物的颜色。肿瘤常生长迅速，具有局部侵袭性。影像学检查表现为边界清楚的透射影，典型的CT影像为边缘不规则的低密度团块，偶有高密度的报道。 MRI的T1加权和T2加权上均表现为低信号团。病理检查常由大的并含不等量色素颗粒的上皮样细胞和小的神经母细胞样细胞组成。目前常用的治疗方法为手术切除，发生恶变及转移的可能性较低，复发率约10％～20％，且多发生于术后6个月以内，定期随访非常重要。
영인흑색소신경외배류（MNTI）시일충소견적、증장신속적신경척래원량성종류，다발생우1세이내영유인。호발부위위상합골전부，하합골적병례소견。본문보도1례발생우하합골병행수술치료적MNTI병례，병통과문헌회고탐토MNTI적병례특점급진단치료요점。구강영인MNTI구유전형적발병부위여발병년령，림상검사시응주의종물적안색。종류상생장신속，구유국부침습성。영상학검사표현위변계청초적투사영，전형적CT영상위변연불규칙적저밀도단괴，우유고밀도적보도。 MRI적T1가권화T2가권상균표현위저신호단。병리검사상유대적병함불등량색소과립적상피양세포화소적신경모세포양세포조성。목전상용적치료방법위수술절제，발생악변급전이적가능성교저，복발솔약10％～20％，차다발생우술후6개월이내，정기수방비상중요。
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, rapidly growing neoplasm of neural crest origin that primarily develops in the maxilla of infants during their first year of life, mandibular lesions are rare. We present a case of a newborn with MNTI involving the anterior mandibular region who are treated by a surgical excision of the lesion with safe margins . A review of literature also been done to discuss the clinicopathological features of MNTI . Oral MNTI appear to occur in certain locations and people of certain age. Special attention should be paid to the color of the tumor during intraoral examination. This tumor grew rapidly and invasively . The typical radiographic appearance of MNTI osseous lesions is a well-demarcated radiolucent lesion with bone-expansion . CT image may show bone expansion and destruction, mostly be low density. MRI image usually shows low signal on both the T1 and T2 weighted sequences. Histologically, MNTI was composed of larger melanin-containing epithelial cells and small neuroblast-like cells . Surgical excision is the common treatment for MNTI. In the literature, a few cases of malignancy have been published. However, the rate of recurrences varies between 10% and 20%, in particular within the first 6 postoperative months . Follow-up is highly recommended.