CAJ | 학술논문

目的：研究北京市社区不同糖代谢状态人群的肥胖指标与动脉硬化的相关性。方法用臂-踝脉搏波传导速度(baPWV)反映动脉硬化程度。对北京市石景山区两个社区大于或等于40岁居民进行体格检查,测量体重(weight)、腰围(WC)、体重指数( BMI)、腰臀比( WHR)、腰围升高比( WHtR)及标准化问卷调查、生化和糖化血红蛋白检测、75 g葡萄糖耐量实验及baPWV测量。对数据资料完整及BMI大于或等于18.5 kg/m2的9080名人员根据75OGTT试验及糖尿病史分为NGT、IGR和DM组,分析BMI、WC、WHR、WHtR与baPWV之间的关系。结果在NGT、IGR、DM组,根据WC、WHR、WHtR分成亚组,中心型肥胖组的baP-WV明显高于正常组(P<0.01),在DM组内,以BMI作为肥胖标准,baPWV仅在NGT和IGR组内有统计学意义,在DM组无显著差异(P>0.05)。在NGT、IGR和DM组内,中心型肥胖指标(WC、WHR、WHtR)与baPWV呈显著正相关(P<0.05),BMI仅在NGT组内与baPWV呈正相关,在IGR和DM组内无明显相关(P>0.05)。校正年龄、性别、心血管危险因素,通过多元回归分析发现, WHR和WHtR每增加0.1,baPWV则随之升高40.6 cm/s和55.3 cm/s。结论在糖代谢异常人群中,中心性肥胖指标(WC、WHR、WHtR)与动脉硬化呈正相关,较BMI更能反映动脉硬化程度。
목적：연구북경시사구불동당대사상태인군적비반지표여동맥경화적상관성。방법용비-과맥박파전도속도(baPWV)반영동맥경화정도。대북경시석경산구량개사구대우혹등우40세거민진행체격검사,측량체중(weight)、요위(WC)、체중지수( BMI)、요둔비( WHR)、요위승고비( WHtR)급표준화문권조사、생화화당화혈홍단백검측、75 g포도당내량실험급baPWV측량。대수거자료완정급BMI대우혹등우18.5 kg/m2적9080명인원근거75OGTT시험급당뇨병사분위NGT、IGR화DM조,분석BMI、WC、WHR、WHtR여baPWV지간적관계。결과재NGT、IGR、DM조,근거WC、WHR、WHtR분성아조,중심형비반조적baP-WV명현고우정상조(P<0.01),재DM조내,이BMI작위비반표준,baPWV부재NGT화IGR조내유통계학의의,재DM조무현저차이(P>0.05)。재NGT、IGR화DM조내,중심형비반지표(WC、WHR、WHtR)여baPWV정현저정상관(P<0.05),BMI부재NGT조내여baPWV정정상관,재IGR화DM조내무명현상관(P>0.05)。교정년령、성별、심혈관위험인소,통과다원회귀분석발현, WHR화WHtR매증가0.1,baPWV칙수지승고40.6 cm/s화55.3 cm/s。결론재당대사이상인군중,중심성비반지표(WC、WHR、WHtR)여동맥경화정정상관,교BMI경능반영동맥경화정도。
Objective To analyze the relationship between obesity and arterial stiffness among population of different glucose tolerance status. Methods A cross-sectional study recruited the population aged 40 years or older from ShiJingShan district in Beijing. 9080 subjects were included by measured weight, waist circumference (WC), body mass index (BMI), waist/hip ratio (WHR) and WC/height ratio (WHtR) and hemodynamic indexes and the aortic stiffness (using brachial-ankle pulse wave velocity(baPWV). They were divided into 3 groups based on the results of OGTT and diabetes history: normal glucose tolerance group ( NGT group) ,impaired glucose regulation group ( IGR group) and diabetes mellitus group ( DM group) . The association between baPWV and different obese indexes was analyzed by multi-ple linear regression. Results According to the criterion of WC, WHR and WHtR, baPWV of central obesity group was significantly higher than the normal group(P<0. 01). There was no statistically significant differences based on BMI in DM group(P>0. 05), but it was of sta-tistically significant differences in NGT group and IGR group. Central obese indexes( WC、WHR、WHtR) showed a positive correlation to PWV in the studied groups(P<0. 05). BMI was only positively correlated with baPWV in NGT group, there was no significant correlation in IGR and DM group(P>0. 05). After adjusting for age, gender and cardiovascular risk factors, the multiple regression analysis found that for every 0. 1 point increase in WHR and WHtR, the PWV increased 40. 6 cm/s and 55. 3cm/s respectively. Conclusion There is a positive correlation between central obese indexes (WC、WHR、WHtR) and arterial stiffness, and the central obese indexes correlated with arterial stiffness better than BMI.