国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
3期
190-195
,共6页
Th17细胞%白细胞介素-17%肿瘤免疫
Th17細胞%白細胞介素-17%腫瘤免疫
Th17세포%백세포개소-17%종류면역
Th17 cells%Interleukin-17%Tumor immunity
Th17细胞是新发现的一群不同于Th1与Th2细胞的CD4+T细胞亚群.Th17细胞以IL-23依赖的方式分泌白细胞介素(IL)-17,在慢性炎症与自身免疫性疾病中发挥重要作用.自2005年发现以来,Th17细胞受到了广泛关注,并已成为免疫学研究的热点.近年来的研究显示,Th17细胞也参与了肿瘤免疫,但对于其是促进肿瘤发生发展还是抑制肿瘤发展尚无定论.
Th17細胞是新髮現的一群不同于Th1與Th2細胞的CD4+T細胞亞群.Th17細胞以IL-23依賴的方式分泌白細胞介素(IL)-17,在慢性炎癥與自身免疫性疾病中髮揮重要作用.自2005年髮現以來,Th17細胞受到瞭廣汎關註,併已成為免疫學研究的熱點.近年來的研究顯示,Th17細胞也參與瞭腫瘤免疫,但對于其是促進腫瘤髮生髮展還是抑製腫瘤髮展尚無定論.
Th17세포시신발현적일군불동우Th1여Th2세포적CD4+T세포아군.Th17세포이IL-23의뢰적방식분비백세포개소(IL)-17,재만성염증여자신면역성질병중발휘중요작용.자2005년발현이래,Th17세포수도료엄범관주,병이성위면역학연구적열점.근년래적연구현시,Th17세포야삼여료종류면역,단대우기시촉진종류발생발전환시억제종류발전상무정론.
Th17 cells are recently identified as a novel CD4+ T cell subset,which is different from Th1 and Th2 lineage.Th17 cells are characterized by the production of IL-17 in an IL-23 dependent way.Their involvement in chronic inflammation and autoimmune diseases has been confirmed.Since identified in 2005,Thl7 cells have been extensively investigated.Recent works have demonstrated that Th17 cells participated in tumor immunity.However,whether these cells promote tumor growth or regulate antitumor responses remains controversial.
