中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
29期
60-62
,共3页
甲状腺%微小癌%中央区淋巴结清扫%基因突变
甲狀腺%微小癌%中央區淋巴結清掃%基因突變
갑상선%미소암%중앙구림파결청소%기인돌변
Thyroid%Microcarcinoma%Central lymph node dissection%Gene mutation
目的 探讨颈侧淋巴结阴性(cN0)甲状腺乳头状微小癌(PTMC)中央区淋巴结转移相关临床病理因素.方法 分析136例cN0PTMC患者的临床资料,并采用PCR方法对其石蜡包膜组织检测BRAFV600E基因突变.结果 136例PTMC患者中央区淋巴结转移率为38.2％(52/136),BRAFV600E基因突变率44.9％(61/136).单因素分析显示中央区淋巴结转移与BRAFV600E基因突变、包膜侵犯有关(P＜0.05),与肿瘤直径的相关性接近显著水平(P=0.057).多因素回归分析显示,BRAFV6600E基因突变、包膜侵犯是影响中央区淋巴结转移的独立因素(P＜0.05).结论 对于BRAFV600E基因突变、包膜侵犯者,应该常规清扫中央区淋巴结.
目的 探討頸側淋巴結陰性(cN0)甲狀腺乳頭狀微小癌(PTMC)中央區淋巴結轉移相關臨床病理因素.方法 分析136例cN0PTMC患者的臨床資料,併採用PCR方法對其石蠟包膜組織檢測BRAFV600E基因突變.結果 136例PTMC患者中央區淋巴結轉移率為38.2％(52/136),BRAFV600E基因突變率44.9％(61/136).單因素分析顯示中央區淋巴結轉移與BRAFV600E基因突變、包膜侵犯有關(P＜0.05),與腫瘤直徑的相關性接近顯著水平(P=0.057).多因素迴歸分析顯示,BRAFV6600E基因突變、包膜侵犯是影響中央區淋巴結轉移的獨立因素(P＜0.05).結論 對于BRAFV600E基因突變、包膜侵犯者,應該常規清掃中央區淋巴結.
목적 탐토경측림파결음성(cN0)갑상선유두상미소암(PTMC)중앙구림파결전이상관림상병리인소.방법 분석136례cN0PTMC환자적림상자료,병채용PCR방법대기석사포막조직검측BRAFV600E기인돌변.결과 136례PTMC환자중앙구림파결전이솔위38.2％(52/136),BRAFV600E기인돌변솔44.9％(61/136).단인소분석현시중앙구림파결전이여BRAFV600E기인돌변、포막침범유관(P＜0.05),여종류직경적상관성접근현저수평(P=0.057).다인소회귀분석현시,BRAFV6600E기인돌변、포막침범시영향중앙구림파결전이적독립인소(P＜0.05).결론 대우BRAFV600E기인돌변、포막침범자,응해상규청소중앙구림파결.
Objective To investigate the clinical pathological factors of papillary thyroid microcarcinoma (PTMC) with clinically node-negative sides of neck stage central lymph node metastasis.Methods Analysis of 136 cases of cNo stage of PTMC of clinical and pathological data,and using the PCR method for the detection of BRAFV600E mutation in the paraffin coated tissue.Results One hundred and thirty-six cases with PTMC lymph node metastasis rate was 38.2％ (52/136),BRAFV600E mutation rate was 44.9％ (61/136).Single factor analysis showed that the lymph node metastasis was related with BRAFV600E mutation and capsular invasion (P＜ 0.05).The size of the tumor was close to significant level (P=0.057).Multiple regression analysis showed that BRAFV600E mutation and capsular invasion were independent factors for affecting the central lymph node metastasis (P ＜ 0.05).Conclusion The routine central lymph node dissection should be performed in patients with BRAFV600E mutation and tumor invasion.
