CAJ | 학술논문

目的：研究肝再生增强因子在匀月灾肝硬化患者中的表达及临床意义。方法选取我院2010年至2013年间确诊的120例匀月灾肝硬化患者为观察组，我院体检科120例健康人1设为对照组，采用耘蕴陨杂A法检测两组人群血清中A蕴砸浓度，运用云蚤遭则燥杂糟葬灶超声检测观察组患者肝硬化的程度。结果观察组的A蕴栽、栽遭蚤造水平明显高于对照组，观察组的A蕴月水平明显低于对照组，差异显著(孕<0.01)；观察组的A蕴砸浓度明显高于对照组，差异显著(孕<0.01)。直线相关分析表明，肝硬化患者的A蕴砸浓度与肝脏云蚤遭则燥杂糟葬灶值呈现负的相关性(则2越-0.197，云越14.687，孕<0.01)。结论患者血清中的A蕴砸在匀月灾肝硬化患者中表达显著增强，与肝脏硬度及腹水的发生呈现负相关，这对临床具有重要的意义。
목적：연구간재생증강인자재균월재간경화환자중적표체급림상의의。방법선취아원2010년지2013년간학진적120례균월재간경화환자위관찰조，아원체검과120례건강인1설위대조조，채용운온운잡A법검측량조인군혈청중A온잡농도，운용운조조칙조잡조장조초성검측관찰조환자간경화적정도。결과관찰조적A온재、재조조조수평명현고우대조조，관찰조적A온월수평명현저우대조조，차이현저(잉<0.01)；관찰조적A온잡농도명현고우대조조，차이현저(잉<0.01)。직선상관분석표명，간경화환자적A온잡농도여간장운조조칙조잡조장조치정현부적상관성(칙2월-0.197，운월14.687，잉<0.01)。결론환자혈청중적A온잡재균월재간경화환자중표체현저증강，여간장경도급복수적발생정현부상관，저대림상구유중요적의의。
Objective To study the expression and clinical significance of liver regeneration augmenter in liver cirrhosis patients with HBV. Methods 120 cases of HBV patients with cirrhosis confirmed in our hospital from 2010 to 2013 were selected as observation group, 120 cases taking physical examnation in our hospital were selected as control group. The serum concentration of ALR was detected by ELISA, and the degree of liver cirrhosis of the observation group was tested by FibroScan ultrasound. Results The ALT, Tbil level of the observation group were obviously higher than those of the control group, and the ALB level of the observation group was significantly lower than that of the control group, with significant difference (P<0.01); the concentration of ALR in patients with cirrhosis was significantly higher than that of the control group, with significant difference (P<0.01). Linear correlation analysis indicated that the ALR concentration and liver FibroScan value of the observation group had negative correlation (r2 = -0.197, F = 14.687, P <0.01). Conclusions ALR expression is significantly enhanced in the serum of HBV patients with cirrhosis, having negative correlation with the liver hardness and the occurrence of ascites, which has important clinical significance.