CAJ | 학술논문

目的：研究芬太尼作术后镇痛药对患者胰岛功能的影响。方法选取符合宰匀韵诊断标准要求的Ⅰ型糖尿病患者50例，将其随机分为Ⅰ组和Ⅱ组各25例。Ⅰ组不给药，Ⅱ组使用作为术后镇痛药物的芬太尼，镇痛泵内配方为：芬太尼1.5皂早+阿扎司琼10皂早+0.9豫晕葬悦造溶液，将其配至100皂蕴，流量为2皂蕴/澡，首量静脉推注芬太尼50μ早。另设一组非糖尿病患者(25例)作为对照组。三组患者分别在术前30皂蚤灶及术后12澡、24澡、48澡、72澡检测血糖及胰岛素水平。结果患者使用芬太尼进行术后镇痛后(Ⅱ组)，在术后12澡、24澡和48澡的血糖明显比未使用者(Ⅰ组)低(孕<0.05)，而两组间的胰岛素分泌无差异(孕>0.05)。结论使用芬太尼进行术后镇痛时，可以更好的控制糖尿病患者的血糖，而对患者的胰岛素分泌无影响。
목적：연구분태니작술후진통약대환자이도공능적영향。방법선취부합재균운진단표준요구적Ⅰ형당뇨병환자50례，장기수궤분위Ⅰ조화Ⅱ조각25례。Ⅰ조불급약，Ⅱ조사용작위술후진통약물적분태니，진통빙내배방위：분태니1.5조조+아찰사경10조조+0.9예훈장열조용액，장기배지100조온，류량위2조온/조，수량정맥추주분태니50μ조。령설일조비당뇨병환자(25례)작위대조조。삼조환자분별재술전30조조조급술후12조、24조、48조、72조검측혈당급이도소수평。결과환자사용분태니진행술후진통후(Ⅱ조)，재술후12조、24조화48조적혈당명현비미사용자(Ⅰ조)저(잉<0.05)，이량조간적이도소분비무차이(잉>0.05)。결론사용분태니진행술후진통시，가이경호적공제당뇨병환자적혈당，이대환자적이도소분비무영향。
Objective To investigate the effect of fentanyl serving as postoperative analgesia drugs on the diabetic patients' islets. Methods 50 cases ofⅠdiabetic patients conformed to the WHO diagnostic criteria were selected and randomly divided into groupⅠ(25 cases) and groupII(25 cases). The groupⅠreceived nothing, while the gorupIIused fentanyl as postoperative analgesia drugs, the dispensing of the analgesia pump were fentanyl (1.5 mg)+azasetron (10 mg)+NaCl (0.9%), then conpounded it to 100 mL, the flow was 2 mL/h, and the first intravenous injection of fentanyl was 50 μg. Patirnts without diabetes were also selected as control group (25 cases). The blood glucose and insulin of three group were detected 30 min preoperatively, and 12 h, 24 h, 48 h, 72 h postoperatively. Results The patients' blood glucose concentration at the time of 12 h, 24 h, 48 h postoperative in groupIIwas significantly lower than those of groupⅠ(P<0.05), but the insulin concentration had no difference between the two groups (P >0.05). Conclusions The application of fentanyl using in postoperative analgesia can better control the blood glucose of the diabetic patients and has no effects on the secretion of insulin.