中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
11期
1960-1962
,共3页
林小明%韦宝含%曾毅%韦平原%梁汉钦%谢伟乾%陈明忠
林小明%韋寶含%曾毅%韋平原%樑漢欽%謝偉乾%陳明忠
림소명%위보함%증의%위평원%량한흠%사위건%진명충
注射用硝普钠%高效液相色谱法%配伍%正交设计
註射用硝普鈉%高效液相色譜法%配伍%正交設計
주사용초보납%고효액상색보법%배오%정교설계
Sodium nitroprusside%HPLC%Compatibility%Orthogonal design
目的：研究注射用硝普钠输液的最佳配伍方案。方法：选择温度、溶媒、溶媒用量、时间4个影响因素,采用L16(43×26)因素水平表,用高效液相色谱法对各样品溶液中的硝普钠含量进行了测定,用GWF-5J 型微粒分析仪对各样品溶液中的微粒含量进行了测定,用pHS-2C型精密酸度计对各样品溶液中的pH进行了测定,并结合综合评分对注射用硝普钠输液的最佳配伍方案进行了优选研究。结果：最佳配伍方案为硝普钠50 mg,溶于250 ml 0.9%氯化钠注射液中,避光下,在26 h内输液质量稳定。结论：该输液配伍方案为临床用药提供了科学依据。
目的：研究註射用硝普鈉輸液的最佳配伍方案。方法：選擇溫度、溶媒、溶媒用量、時間4箇影響因素,採用L16(43×26)因素水平錶,用高效液相色譜法對各樣品溶液中的硝普鈉含量進行瞭測定,用GWF-5J 型微粒分析儀對各樣品溶液中的微粒含量進行瞭測定,用pHS-2C型精密痠度計對各樣品溶液中的pH進行瞭測定,併結閤綜閤評分對註射用硝普鈉輸液的最佳配伍方案進行瞭優選研究。結果：最佳配伍方案為硝普鈉50 mg,溶于250 ml 0.9%氯化鈉註射液中,避光下,在26 h內輸液質量穩定。結論：該輸液配伍方案為臨床用藥提供瞭科學依據。
목적：연구주사용초보납수액적최가배오방안。방법：선택온도、용매、용매용량、시간4개영향인소,채용L16(43×26)인소수평표,용고효액상색보법대각양품용액중적초보납함량진행료측정,용GWF-5J 형미립분석의대각양품용액중적미립함량진행료측정,용pHS-2C형정밀산도계대각양품용액중적pH진행료측정,병결합종합평분대주사용초보납수액적최가배오방안진행료우선연구。결과：최가배오방안위초보납50 mg,용우250 ml 0.9%록화납주사액중,피광하,재26 h내수액질량은정。결론：해수액배오방안위림상용약제공료과학의거。
Objective:To investigate the best compatibility plan for nitroprusside sodium for injection. Methods: An L16 (43 × 26 ) orthogonal design was used with four factors:temperature, solvent, solvent volume and time. The content of sodium nitroprusside was detected by HPLC, the insoluble particles were observed by a GWF-5J type particle analyzer, pH was detected by a PHS-2C preci-sion acidity meter, and a comprehensive scoring method was used to optimize the compatibility plan. Results:The optimized compati-bility plan was as follows:50mg sodium nitroprusside was dissolved in 250ml sodium chloride injections, avoiding light and used up in 26h. Conclusion:The plan provides scientific basis for the clinical medication.
