CAJ | 학술논문

目的：分析干预前后我院抗菌药临床应用情况及临床分离菌对常用抗菌药的耐药情况。方法：利用信息检索系统,查询我院2012第一季度(干预前)、2013年第一季度(干预后)抗菌药消耗量,对抗菌药的用药频度( DDDs)进行排名及细菌对临床常见抗菌药耐药率进行分析。结果：干预前后排名前十的抗菌药相差较大,但仍都以头孢菌素类为主,DDDs整体下降明显。细菌的分离率和分布情况基本保持不变。肠杆菌科大肠埃希菌ESBLs产酶率降低了7.61%,肺炎克雷伯菌ESBLs产酶率降低了1.34%,对常用抗菌药的耐药率整体下降。相比革兰阳性葡萄球菌对常用抗菌药的耐药率降低。革兰阳性肠球菌对常用抗菌药的耐药率相差较大。结论：干预后我院抗菌药DDDs和细菌的耐药率整体下降,但并不是所有细菌的耐药率均下降,因此,临床治疗用抗菌药时应尽早做药敏试验,根据药敏试验结果选药。
목적：분석간예전후아원항균약림상응용정황급림상분리균대상용항균약적내약정황。방법：이용신식검색계통,사순아원2012제일계도(간예전)、2013년제일계도(간예후)항균약소모량,대항균약적용약빈도( DDDs)진행배명급세균대림상상견항균약내약솔진행분석。결과：간예전후배명전십적항균약상차교대,단잉도이두포균소류위주,DDDs정체하강명현。세균적분리솔화분포정황기본보지불변。장간균과대장애희균ESBLs산매솔강저료7.61%,폐염극뢰백균ESBLs산매솔강저료1.34%,대상용항균약적내약솔정체하강。상비혁란양성포도구균대상용항균약적내약솔강저。혁란양성장구균대상용항균약적내약솔상차교대。결론：간예후아원항균약DDDs화세균적내약솔정체하강,단병불시소유세균적내약솔균하강,인차,림상치료용항균약시응진조주약민시험,근거약민시험결과선약。
Objective:To analyze the use status of antibiotics and the resistance of clinic isolate bacteria against the commonly used antibiotics before and after the intervention. Methods:Using the information retrieval systems, the consumption of antibiotics in the inpatients during the 1st quarter of 2012(before the intervention) and the same period of 2013(after the intervention) was com-pared. According to the defined daily dose ( DDDs) , the antibiotics were ranked, and the resistance rate against the commonly used antibiotics was analyzed. Results:Compared with the top ten before the intervention, the top ten after the intervention was changed sig-nificantly, however, cephalosporins was still the main species. After the intervention, the overall decline in DDDs was significant, the separation rate and distribution of bacteria remained stable. ESBLs enzyme production rate of Enterobacteriaceae Escherichia coli was re-duced by 7. 61%, and that of Klebsiella pneumoniae was reduced by 1. 34%, and the resistance rate against the commonly used antibi-otics was in an overall downward trend. The resistance rate of Gram-positive staphylococci against the commonly used antibiotics was de-creased, while that of Gram-positive enterococci showed notable difference. Conclusion:The DDDs of antibiotics and bacterial resist-ance rate are in an overall downward trend in our hospital after the intervention;however, there is still exception. Therefore, the clini-cal antimicrobial susceptibility tests should be performed as soon as possible to help the choice of antibiotics.