CAJ | 학술논문

目的：研究三七叶总皂苷脂质体凝胶剂的制备方法，并进行质量评价。方法：以薄膜分散法制备脂质体，通过正交试验设计优化三七叶总皂苷脂质体的处方。采用高速离心法测定其包封率，以包封率的高低做为脂质体优劣的评价指标，筛选出制备脂质体的最佳工艺。并进一步制备成凝胶，采用高效液相色谱法测定其中人参皂苷Rb3的含量，并初步观察其稳定性。结果：所制凝胶剂为半透明粘稠状胶体，考察符合《中国药典》2010年版的相关规定，稳定性良好，皮肤刺激性小。结论：本制剂制备工艺简单可行，检测方法可靠，质量稳定可控。
목적：연구삼칠협총조감지질체응효제적제비방법，병진행질량평개。방법：이박막분산법제비지질체，통과정교시험설계우화삼칠협총조감지질체적처방。채용고속리심법측정기포봉솔，이포봉솔적고저주위지질체우렬적평개지표，사선출제비지질체적최가공예。병진일보제비성응효，채용고효액상색보법측정기중인삼조감Rb3적함량，병초보관찰기은정성。결과：소제응효제위반투명점주상효체，고찰부합《중국약전》2010년판적상관규정，은정성량호，피부자격성소。결론：본제제제비공예간단가행，검측방법가고，질량은정가공。
Objective:To study the preparation of total leaves saponins of panax notoginseng liposomal gels and evaluate the quali-ty. Methods:The total leaves saponins of panax notoginseng liposomes were prepared by the film-dispersion method, and the formula was optimized by the orthogonal experimental design. A high-speed centrifugation method was applied to determine the encapsulation efficiency used as the evaluation index for the optimization of the preparation process. Then the gels were prepared and an HPLC meth-od was used to determine the content of ginsenoside Rb3 . The stability was preliminarily studied as well. Results:The preparation was semi-solid, and viscous gels with low skin irritation and good stability. The quality was accordance with the relevant provisions in Chi-nese Pharmacopoeia (2010 edition). Conclusion: The gels are with the properties of simple preparation process, reliable detection methods and stable and controllable quality.