CAJ | 학술논문

手性β-氨基酸是一类在药物开发和生物研究中具有广泛应用的中间体，尝试了以L-天冬氨酸为手性源合成手性β-氨基酸的研究，其合成方法：首先对天冬氨酸进行氨基保护，然后利用微波，高效地合成（ S）-N-保护的丝氨酸-γ-内酯，最后通过傅克反应，合成具有芳香性的手性β氨基酸。具有路线短、操作方便、绿色经济等优点，适合工业化大生产。
수성β-안기산시일류재약물개발화생물연구중구유엄범응용적중간체，상시료이L-천동안산위수성원합성수성β-안기산적연구，기합성방법：수선대천동안산진행안기보호，연후이용미파，고효지합성（ S）-N-보호적사안산-γ-내지，최후통과부극반응，합성구유방향성적수성β안기산。구유로선단、조작방편、록색경제등우점，괄합공업화대생산。
Chiral β-amino acids were intermediates , having a wide range of applications in biological research and drug development.Trying to use L-aspartic acid as chiral pool to synthesis β-amino acids , the synthesis method was that protecting the amino group of aspartic acid , then the microwave efficiently synthesized ( S ) -N -protected homoserine γ-lactone , and aromatic chiral βamino acids through Friedel -Crafts reaction was obtained , which had the characteristics of a line short , easy to operate , green economy , suitable for industrial production , etc.