检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
21期
2992-2994
,共3页
丹参川穹嗪%甲钴胺%糖尿病周围神经病变%神经传导速度%血流变
丹參川穹嗪%甲鈷胺%糖尿病週圍神經病變%神經傳導速度%血流變
단삼천궁진%갑고알%당뇨병주위신경병변%신경전도속도%혈류변
Danshen ligustrazin%mecobalamine%diabetic peripheral neuropathy%nerve conduction veloc-ity%hemorheology
目的：探讨丹参川穹嗪联合甲钴胺对糖尿病周围神经病变患者神经传导速度及血流变学的影响。方法将84例糖尿病周围神经病变患者随机分成观察组与对照组，每组42例。两组患者均严格控制血糖，观察组患者给予丹参川穹嗪联合甲钴胺静脉滴注治疗，对照组给予甲钴胺静脉滴注治疗，两组疗程均为4周。观察两组患者临床疗效、神经传导速度及血流变学的变化。结果观察组患者总有效率、感觉正中神通经、腓神经传导速度、运动正中神经、腓神经传导速度、血管内径变化率明显高于对照组；空腹血糖、总胆固醇（TC）、三酰甘油（TG）、血浆黏度、高切黏度、低切黏度、收缩期血管峰值血流速度（PS V ）、内膜中层厚度（IM T ）、管径狭窄率均明显低于对照组（P＜0．05）。结论丹参川穹嗪联合甲钴胺治疗糖尿病周围神经病变患者临床疗效明显，有效提高神经传导速度，改善血液流变学状态。
目的：探討丹參川穹嗪聯閤甲鈷胺對糖尿病週圍神經病變患者神經傳導速度及血流變學的影響。方法將84例糖尿病週圍神經病變患者隨機分成觀察組與對照組，每組42例。兩組患者均嚴格控製血糖，觀察組患者給予丹參川穹嗪聯閤甲鈷胺靜脈滴註治療，對照組給予甲鈷胺靜脈滴註治療，兩組療程均為4週。觀察兩組患者臨床療效、神經傳導速度及血流變學的變化。結果觀察組患者總有效率、感覺正中神通經、腓神經傳導速度、運動正中神經、腓神經傳導速度、血管內徑變化率明顯高于對照組；空腹血糖、總膽固醇（TC）、三酰甘油（TG）、血漿黏度、高切黏度、低切黏度、收縮期血管峰值血流速度（PS V ）、內膜中層厚度（IM T ）、管徑狹窄率均明顯低于對照組（P＜0．05）。結論丹參川穹嗪聯閤甲鈷胺治療糖尿病週圍神經病變患者臨床療效明顯，有效提高神經傳導速度，改善血液流變學狀態。
목적：탐토단삼천궁진연합갑고알대당뇨병주위신경병변환자신경전도속도급혈류변학적영향。방법장84례당뇨병주위신경병변환자수궤분성관찰조여대조조，매조42례。량조환자균엄격공제혈당，관찰조환자급여단삼천궁진연합갑고알정맥적주치료，대조조급여갑고알정맥적주치료，량조료정균위4주。관찰량조환자림상료효、신경전도속도급혈류변학적변화。결과관찰조환자총유효솔、감각정중신통경、비신경전도속도、운동정중신경、비신경전도속도、혈관내경변화솔명현고우대조조；공복혈당、총담고순（TC）、삼선감유（TG）、혈장점도、고절점도、저절점도、수축기혈관봉치혈류속도（PS V ）、내막중층후도（IM T ）、관경협착솔균명현저우대조조（P＜0．05）。결론단삼천궁진연합갑고알치료당뇨병주위신경병변환자림상료효명현，유효제고신경전도속도，개선혈액류변학상태。
Objective To study the influence of Danshen ligustrazin combined with mecobalamine on the nerve conduction velocity and hemorheology in the patients with diabetic peripheral neuropathy .Methods 84 patients with diabetic peripheral neuropathy were divided into the observation group and the control group ,42 cases in each group . The blood sugar in the two group was strictly controlled .The observation group was given Danshen ligustrazin com-bined with mecobalamine by intravenous drip ,while the control group was given intravenous drip of mecobalamine with the treatment course of 4 weeks .The clinical efficacy and the change of nerve the conduction velocity and hemor-rheology were observed in the two groups .Results The total effective rate ,conduction velocity of median and pero-neal sensory nerve ,conduction velocity of median and peroneal motor nerve and change rate of blood vessel diameter in the observation group were significantly higher than those in the control group ;while fasting blood glucose ,TC , TG ,plasma viscosity ,high shear viscosity ,low shear viscosity ,PSV ,IMT and diameter stenosis rate were significant-ly lower than those in the control group(P<0 .05) .Conclusion Danshen ligustrazin combined with mecobalamine has distinct clinical effect for treating diabetic peripheral neuropathy ,effectively increase the nerve conduction velocity and improve the hemorheologic state .
