CAJ | 학술논문

目的：探讨血浆D-二聚体在诊断肝病方面的临床应用价值。方法选择2013年1～10月确诊为肝病的患者100例设为试验组，选择同期体检健康者100例设为对照组，均进行血浆D-二聚体检测，同时对常规检测指标血清丙氨酸氨基转移酶、前清蛋白水平进行检测，对检测结果进行统计分析。结果与对照组比较，试验组患者血浆D-二聚体、血清丙氨酸氨基转移酶水平均有明显提高（P＜0．05），血清前清蛋白水平有明显下降（P＜0．05）；血浆D-二聚体的阳性检出率（80．0％以上）明显高于常规检测指标（ P＜0．05）。结论血浆D-二聚体水平变化可准确了解肝病患者体内高凝状态和肝细胞的合成功能，有助于提高对肝病检测的阳性检出率，可为临床肝脏疾病的分期、严重程度、治疗情况及判断预后提供依据。
목적：탐토혈장D-이취체재진단간병방면적림상응용개치。방법선택2013년1～10월학진위간병적환자100례설위시험조，선택동기체검건강자100례설위대조조，균진행혈장D-이취체검측，동시대상규검측지표혈청병안산안기전이매、전청단백수평진행검측，대검측결과진행통계분석。결과여대조조비교，시험조환자혈장D-이취체、혈청병안산안기전이매수평균유명현제고（P＜0．05），혈청전청단백수평유명현하강（P＜0．05）；혈장D-이취체적양성검출솔（80．0％이상）명현고우상규검측지표（ P＜0．05）。결론혈장D-이취체수평변화가준학료해간병환자체내고응상태화간세포적합성공능，유조우제고대간병검측적양성검출솔，가위림상간장질병적분기、엄중정도、치료정황급판단예후제공의거。
Objective To explore the clinical application value of plasma D-dimer in diagnosing liver diseases . Methods 100 cases of liver diseases from January to October 2013 were selected as the experimental group and con-temporaneous 100 cases of healthy check-up as the the control group .The plasma D-dimer was detected .At the same time ALT and albumin were detected .Then the detection results were statistically analyzed .Results Compared with the control group ,the plasma D-dimer and serum ALT in the experimental group were significantly increased (P<0 .05) ,and serum albumin was significantly decreased (P<0 .05);the positive detection rate of plasma D-dimer was over 80 .0% ,which was significantly higher than that of the conventional detection indexes (P<0 .05) .Conclusion The hypercoagulable state in vivo and the synthetic function of liver cells in the patients with liver disease can be accu-rately understood by the change of plasma D-dimer levels ,w hich conduces to improve the positive detection rate of liver dis-eases and can provide the basis for judging the stage ,severity ,treatment situation and prognosis of liver diseases .