CAJ | 학술논문

目的：分析乙型肝炎表面抗原（HBsAg）和乙型肝炎表面抗体（抗-HBs）同时阳性的乙型肝炎病毒（HBV ）感染者病毒学特征动态变化。方法对53例 HBsAg和抗-HBs同时阳性患者进行平均13．5个月的随访，检测随访前后血清 HBV标志物，并对 HBV DNA进行定量检测及丙氨酸氨基转移酶（ALT）检测，分析其病毒学特征变化特点。结果53例患者随访期间，4例（7．55％）HBsAg转为阴性，13例（24．53％）抗-HBs转为阴性，而36例（67．92％）HBsAg和抗-HBs仍同时为阳性。随访后患者血清 HBsAg与抗-HBs水平、乙型肝炎e抗原（HBeAg ）阳性率及ALT水平与随访前相比差异无统计学意义（P＞0．05），随访后 HBV DNA水平（3．44±1．60log10）IU/mL较随访前（3．00±1．36）log10 IU/mL降低，差异有统计学意义（P＜0．05）。结论大多数 HBsAg与抗-HBs同时阳性的HBV感染者抗原与抗体可长期存在，HBsAg及HBV DNA水平较低、HBeAg阴性患者更易发生HBsAg转阴。
목적：분석을형간염표면항원（HBsAg）화을형간염표면항체（항-HBs）동시양성적을형간염병독（HBV ）감염자병독학특정동태변화。방법대53례 HBsAg화항-HBs동시양성환자진행평균13．5개월적수방，검측수방전후혈청 HBV표지물，병대 HBV DNA진행정량검측급병안산안기전이매（ALT）검측，분석기병독학특정변화특점。결과53례환자수방기간，4례（7．55％）HBsAg전위음성，13례（24．53％）항-HBs전위음성，이36례（67．92％）HBsAg화항-HBs잉동시위양성。수방후환자혈청 HBsAg여항-HBs수평、을형간염e항원（HBeAg ）양성솔급ALT수평여수방전상비차이무통계학의의（P＞0．05），수방후 HBV DNA수평（3．44±1．60log10）IU/mL교수방전（3．00±1．36）log10 IU/mL강저，차이유통계학의의（P＜0．05）。결론대다수 HBsAg여항-HBs동시양성적HBV감염자항원여항체가장기존재，HBsAg급HBV DNA수평교저、HBeAg음성환자경역발생HBsAg전음。
Objective To analyze the dynamic change of virological characteristics in hepatitis B patients with coexistence of HBsAg and anti-HBs .Methods 53 patients with coexistence of HBsAg/anti-HBs were followed up for average 13 .5 months .ALT ,HBV serological markers and HBV DNA were detected before and after follow up . Results During follow-up ,4 cases(7 .55% )showed HBsAg negative conversion ,13 cases(24 .53% )presented anti-HBs negative conversion and 36 cases(67 .92% )had still positive HBsAg and anti-HBs .After follow-up ,the serum levels of HBsAg ,anti-HBs ,positive rate of HBeAg as well as ALT had no statistical differences compared with be-fore follow up(P>0 .05) ,while the level of HBV DNA was decreased from (3 .44 ± 1 .60)log10 IU/mL to (3 .00 ± 1 . 36)log10 IU/mL ,the difference had statistical significance(P<0 .05) .Conclusion Most of hepatitis B virus infected individuals with simultaneously positive HBsAg and anti-HBs may have the long term existence of allergen and anti-body ,the levels of HBsAg and HBV DNA are lower and the patients with negative HBeAg are easy to happen the HBsAg negative conversion .