CAJ | 학술논문

以4-羟基-4’-氯二苯甲酮和氯仿为原料, TEBA为催化剂,在氢氧化钾水溶液存在的条件下合成了非诺贝特酸。考察了氢氧化钾溶液浓度、催化剂用量、滴加氯仿温度和氯仿用量等因素对非诺贝特酸产率的影响。确定最佳反应条件为：4-羟基-4’-氯二苯甲酮30 g,丙酮120 g,氯仿40 g, TEBA 2．5 g,氢氧化钾水溶液浓度50%,反应温度30℃,产率可达89．7%。
이4-간기-4’-록이분갑동화록방위원료, TEBA위최화제,재경양화갑수용액존재적조건하합성료비낙패특산。고찰료경양화갑용액농도、최화제용량、적가록방온도화록방용량등인소대비낙패특산산솔적영향。학정최가반응조건위：4-간기-4’-록이분갑동30 g,병동120 g,록방40 g, TEBA 2．5 g,경양화갑수용액농도50%,반응온도30℃,산솔가체89．7%。
TEBA was used as phase - transfer catalyst to synthesize Fenofibrate acid from 4 - hydroxy -4 ’ -chlorobenzophenone and chloroform in water solution of potassium hydroxide with acetone as solvent. The effects of factors such as the concentration of water solution of potassium hydroxide, the catalyst of TEBA, the reaction temperature and the catalyst of chloroform on the yield were examined. The optimal reaction conditions determined were that 4-hydroxy-4 ’-chlorobenzophenone catalyst was 30 g, acetone catalyst was 120 g, chloroform catalyst was 40 g, TEBA catalyst was 2. 5 g, the concentration of water solution of potassium hydroxide was 50%, reaction temperature was 30 ℃, and the yield reached 89. 7%.