CAJ | 학술논문

[1,2,4]三唑并[4,3-a]喹啉具有杀菌,抗结核,抗肿瘤,抗惊厥活性等多种生理活性,是抗惊厥药物研究的热点之一,有着极为广阔的研究和开发前景。本文以喹啉环和三唑环的构建方法为基础,对近年来喹啉并三唑类抗惊厥药物的合成进行了简要综述。喹啉环的构建方法包括传统的酸催化法、酶催化法、微波催化法及其他催化法；三唑环的构建主要有硫代酰胺法和氯代亚胺法,最后本文还对[1,2,4]三唑并[4,3-a]喹啉抗惊厥药物的研究前景进行了展望。
[1,2,4]삼서병[4,3-a]규람구유살균,항결핵,항종류,항량궐활성등다충생리활성,시항량궐약물연구적열점지일,유착겁위엄활적연구화개발전경。본문이규람배화삼서배적구건방법위기출,대근년래규람병삼서류항량궐약물적합성진행료간요종술。규람배적구건방법포괄전통적산최화법、매최화법、미파최화법급기타최화법；삼서배적구건주요유류대선알법화록대아알법,최후본문환대[1,2,4]삼서병[4,3-a]규람항량궐약물적연구전경진행료전망。
1,2,4] triazolo[4,3 -a] quinoline compounds had a variety of pharmacological activities, such as antifungal, antituberculous, anticancer, anticonvulsion, and became a highlight in the field of anticonvulsants. The recent progress was reviewed according to the methods of building ring-framework. Synthetic methods of building quinoline ring included using traditional acid catalyst, enzyme catalyst, microwave catalyst and other catalyst. the methods of construction of triazole involved thioamide and chloro-imine intermediates. Finally, a vision of further study of 1,2,4-triazolo[4,3-a]quinoline anti-convulsion drugs was also proposed.