CAJ | 학술논문

苯( benzene)是一种常见的职业性毒物和环境污染物,主要由其代谢产物氢醌( Hydroquinone, HQ)发挥毒性作用。聚腺苷二磷酸核糖聚合酶[ Poly ( ADP-ribose) polymerase, PARP]是一类存在于多数真核细胞内的多功能蛋白质翻译后修饰酶,其中PARP-l 是研究最早、最为深入的一种。 PARP -1在氢醌诱导细胞凋亡中发挥了重要作用。本文从 HQ 的概述、PARP-1的结构与功能以及PARP-1在HQ诱导细胞凋亡中的作用等方面做一综述,以期对苯暴露引起的各类疾病的防治提供理论指导。
분( benzene)시일충상견적직업성독물화배경오염물,주요유기대사산물경곤( Hydroquinone, HQ)발휘독성작용。취선감이린산핵당취합매[ Poly ( ADP-ribose) polymerase, PARP]시일류존재우다수진핵세포내적다공능단백질번역후수식매,기중PARP-l 시연구최조、최위심입적일충。 PARP -1재경곤유도세포조망중발휘료중요작용。본문종 HQ 적개술、PARP-1적결구여공능이급PARP-1재HQ유도세포조망중적작용등방면주일종술,이기대분폭로인기적각류질병적방치제공이론지도。
Benzene was a common occupational toxicology and environmental pollutants, which mainly played toxicity by its metabolite hydroquinone. Poly ( ADP-ribose) polymerase was a latter category of multifunctional protein post-translational modification enzymes existing in the majority of eukaryotic cells, while PARP-1 was studied as the earliest and most thorough one. PARP-1 played an important role in the induction of cell apoptosis by hydroquinone. Outlines of the HQ, PARP-1 structure and function as well as aspects of PARP -1 role in the induction of cell apoptosis were reviewed, expecting to prevention and treatment of various diseases caused by benzene exposure and providing theoretical guidance.