CAJ | 학술논문

目的：探讨幽门螺杆菌（H P ）感染患者外周血中T h17及T h22细胞的改变。方法收集H P感染者66例（H P感染组）及体检健康者30例（对照组），采用流式细胞术检测外周血中Th17与Th22细胞水平，同时采用 ELISA法检测血清中IL-17与IL-22的表达水平。结果与对照组比较，H P感染组 T h17、T h22、IL-17、IL-22水平均显著升高，差异有统计学意义（ P＜0．05）。相关分析显示，HP感染患者的HP感染者活度值（DPM）与Th17、Th22、IL-17、IL-22水平均呈正相关（P＜0．01）。结论H P感染患者体内存在T h17与T h22细胞的激活，同时引起相关免疫效应分子IL-17、IL-22的高表达，促进免疫损害的进展。
목적：탐토유문라간균（H P ）감염환자외주혈중T h17급T h22세포적개변。방법수집H P감염자66례（H P감염조）급체검건강자30례（대조조），채용류식세포술검측외주혈중Th17여Th22세포수평，동시채용 ELISA법검측혈청중IL-17여IL-22적표체수평。결과여대조조비교，H P감염조 T h17、T h22、IL-17、IL-22수평균현저승고，차이유통계학의의（ P＜0．05）。상관분석현시，HP감염환자적HP감염자활도치（DPM）여Th17、Th22、IL-17、IL-22수평균정정상관（P＜0．01）。결론H P감염환자체내존재T h17여T h22세포적격활，동시인기상관면역효응분자IL-17、IL-22적고표체，촉진면역손해적진전。
Objective To investigate the changes of Th17 and Th22 cells in patients with Helicobacter pylori(HP)infection . Methods 66 cases of HP infection (HP infection group) and 30 cases of healthy people (control group) were selected .The levels of Th17 and Th22 cells in peripheral blood were measured by flow cytometry and the level of IL-17 and IL-22 in serum were meas-ured by ELISA .Results Comparing with the control group ,the levels of Th17 ,Th22 ,IL-17 and IL-22 were significantly increased in HP infection group(P<0 .05) .The correlation analysis showed that the levels of Th17 ,Th22 ,IL-17 and IL-22 were significantly positive correlated with DPM(P<0 .01) .Conclusion Th17 and Th22 cells were actived in patients with HP infection ,which caused the high expression of immune effector molecules ,and promoted the progress of immune damage .