国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
21期
2899-2900
,共2页
多发性骨髓瘤%肾损伤%胱抑素C%视黄醇结合蛋白
多髮性骨髓瘤%腎損傷%胱抑素C%視黃醇結閤蛋白
다발성골수류%신손상%광억소C%시황순결합단백
multiple myeloma%renal impairment%cystatin-C%retinol binding protein
目的:探讨血清胱抑素C(Cys-C)、尿视黄醇结合蛋白(RBP)对多发性骨髓瘤(MM)患者早期肾损伤的诊断价值。方法根据肾小球滤过率估计值(eGFR)将MM患者分为两组:A组为肾功能正常组(eGFR≥90 mL/min)78例;B组为肾功能损伤组(eGFR<90 mL/min)40例。130例健康体检者作为对照组。检测并比较各组血清Cys-C、尿RBP、血清尿素氮(UN)、血清肌酐(Cr)水平。结果 A组MM患者Cys-C和RBP水平与对照组比较,差异有统计学意义(P<0.01),B组Cys-C、Cr、UN、尿RBP水平均显著高于对照组(P<0.01)。Cys-C和尿RBP联合检测的阳性率为57.69%,明显高于单项检测(P<0.05)。结论 Cys-C和RB P比传统指标能更有效地诊断M M患者早期肾损伤,联合检测具有重要价值。
目的:探討血清胱抑素C(Cys-C)、尿視黃醇結閤蛋白(RBP)對多髮性骨髓瘤(MM)患者早期腎損傷的診斷價值。方法根據腎小毬濾過率估計值(eGFR)將MM患者分為兩組:A組為腎功能正常組(eGFR≥90 mL/min)78例;B組為腎功能損傷組(eGFR<90 mL/min)40例。130例健康體檢者作為對照組。檢測併比較各組血清Cys-C、尿RBP、血清尿素氮(UN)、血清肌酐(Cr)水平。結果 A組MM患者Cys-C和RBP水平與對照組比較,差異有統計學意義(P<0.01),B組Cys-C、Cr、UN、尿RBP水平均顯著高于對照組(P<0.01)。Cys-C和尿RBP聯閤檢測的暘性率為57.69%,明顯高于單項檢測(P<0.05)。結論 Cys-C和RB P比傳統指標能更有效地診斷M M患者早期腎損傷,聯閤檢測具有重要價值。
목적:탐토혈청광억소C(Cys-C)、뇨시황순결합단백(RBP)대다발성골수류(MM)환자조기신손상적진단개치。방법근거신소구려과솔고계치(eGFR)장MM환자분위량조:A조위신공능정상조(eGFR≥90 mL/min)78례;B조위신공능손상조(eGFR<90 mL/min)40례。130례건강체검자작위대조조。검측병비교각조혈청Cys-C、뇨RBP、혈청뇨소담(UN)、혈청기항(Cr)수평。결과 A조MM환자Cys-C화RBP수평여대조조비교,차이유통계학의의(P<0.01),B조Cys-C、Cr、UN、뇨RBP수평균현저고우대조조(P<0.01)。Cys-C화뇨RBP연합검측적양성솔위57.69%,명현고우단항검측(P<0.05)。결론 Cys-C화RB P비전통지표능경유효지진단M M환자조기신손상,연합검측구유중요개치。
Objective To discuss the diagnostic value of serum cystatin-C(Cys-C) and urinary retinol binding protein(RBP) for the early renal impairment in multiple myeloma(MM) patients .Methods According to estimated glomerular filtration rate(eGFR) , the MM patients were divided into two groups :the normal renal function group(eGFR≥90 mL/min ,n=78)marked group A ,the renal impairment group(eGFR<90 mL/min ,n=40)marked group B .130 healthy subjects were selected as control group .The con-centrations of serum Cys-C ,urinary RBP ,serum creatinine(Cr) and serum urea nitrogen(UN) were measured and compared .Results The levels of Cys-C and RBP in group A were significantly higher than those in the control group(P<0 .01) .There were signifi-cant difference of the levels of Cys-C ,Cr ,UN and RBP levels between group B and control group(P<0 .01) .The sensitivity of the combined detection of Cys-C and RBP was 57 .69% ,significantly higher than single index test(P<0 .05) .Conclusion Compared with traditional biomarkers ,Cys-C and RBP are more sensitive and effective indexes for the diagnosis of early renal impairment in the patients with MM ,and jointed detection of the two biomarkers has important value .