CAJ | 학술논문

目的：探讨妊娠糖尿病患者胰岛素抵抗和胰岛β细胞分泌功能变化情况，以期提高临床诊治水平。方法随机选取99例妊娠中晚期孕妇为研究对象，分成3组（糖耐量正常组、糖耐量减低组和妊娠糖尿病组），采用HOM A模型和相关指标评价3组孕妇的胰岛素抵抗和胰岛β细胞分泌功能。结果3组孕妇的血压和血脂水平比较差异无统计学意义（P＞0．05）。3组两两间进行葡萄糖输注速率、第一时相胰岛素分泌量、第二时相胰岛素分泌量、空腹葡萄糖、空腹胰岛素、胰岛素抵抗指数（HOM A-IR）、β细胞功能指数（HOMA-β）的比较，差异均有统计学意义（P＜0．05）。结论妊娠中晚期孕妇随着糖耐量异常的进展胰岛素抵抗逐渐加重，胰岛β细胞功能渐进性减退。
목적：탐토임신당뇨병환자이도소저항화이도β세포분비공능변화정황，이기제고림상진치수평。방법수궤선취99례임신중만기잉부위연구대상，분성3조（당내량정상조、당내량감저조화임신당뇨병조），채용HOM A모형화상관지표평개3조잉부적이도소저항화이도β세포분비공능。결과3조잉부적혈압화혈지수평비교차이무통계학의의（P＞0．05）。3조량량간진행포도당수주속솔、제일시상이도소분비량、제이시상이도소분비량、공복포도당、공복이도소、이도소저항지수（HOM A-IR）、β세포공능지수（HOMA-β）적비교，차이균유통계학의의（P＜0．05）。결론임신중만기잉부수착당내량이상적진전이도소저항축점가중，이도β세포공능점진성감퇴。
Objective To investigate the insulin resistance and the changes of pancreaticβ-cell function in order to improve the clinical diagnosis and therapy .Methods 99 cases of pregnant women in the late ministers were randomly selected for the study and divided into three groups(normal glucose tolerance group ,impaired glucose tolerance group ,and gestational diabetes group) .The in-sulin resistance and isletβ-cell function of the three groups were evaluated by HOMA model and its related indicators .Results The blood pressure and blood lipid level was not significant different among the three groups(P>0 .05) .Pairwise comparisons of glu-cose infusion rate ,the first phase insulin secretion ,the second phase insulin secretion ,fasting glucose ,fasting insulin ,HOM A-IR , and HOMA-βwere made among the three groups ,and there were difference with statistical significance(P<0 .05) .Conclusion The situation of insulin resistance and the dysfunction of pancreaticβ-cell in trimester pregnant women would become bad associated with the abnormal glucose tolerance .