CAJ | 학술논문

目的：探讨血清降钙素原（PCT ）、超敏C反应蛋白（hs-CRP）定量检测在血流感染（BSI）早期诊断中的临床价值。方法检测58例BSI患者（试验组）和58例非BSI患者（对照组）血清PCT、hs-CRP水平，利用受试者工作特征（ROC）曲线评价PCT、hs-CRP对BSI的早期诊断价值。结果试验组和对照组血清 PCT、hs-CRP水平差异均有统计学意义（P＜0．05），血清PCT、hs-CRP诊断BSI的ROC AUC分别为0．902（95％置信区间：0．850～0．955）、0．706（95％置信区间：0．611～0．801），以2．24 ng/mL作为最佳截断值时，PCT对BSI的诊断灵敏度、特异度、阳性预测值、阴性预测值分别为77．6％、91．4％、90．0％、80．3％。以64．83 mg/L作为最佳截断值时，hs-CRP对BSI的诊断灵敏度、特异度、阳性预测值、阴性预测值分别为74．1％、62．1％、54．4％、59．5％。结论血清PCT、hs-CRP定量检测在BSI早期诊断中具有重要的临床价值。
목적：탐토혈청강개소원（PCT ）、초민C반응단백（hs-CRP）정량검측재혈류감염（BSI）조기진단중적림상개치。방법검측58례BSI환자（시험조）화58례비BSI환자（대조조）혈청PCT、hs-CRP수평，이용수시자공작특정（ROC）곡선평개PCT、hs-CRP대BSI적조기진단개치。결과시험조화대조조혈청 PCT、hs-CRP수평차이균유통계학의의（P＜0．05），혈청PCT、hs-CRP진단BSI적ROC AUC분별위0．902（95％치신구간：0．850～0．955）、0．706（95％치신구간：0．611～0．801），이2．24 ng/mL작위최가절단치시，PCT대BSI적진단령민도、특이도、양성예측치、음성예측치분별위77．6％、91．4％、90．0％、80．3％。이64．83 mg/L작위최가절단치시，hs-CRP대BSI적진단령민도、특이도、양성예측치、음성예측치분별위74．1％、62．1％、54．4％、59．5％。결론혈청PCT、hs-CRP정량검측재BSI조기진단중구유중요적림상개치。
Objective To investigate the clinical value of detection of procalcitonin(PCT ) and high sensitivity C-reactive protein (hs-CRP) in early diagnosis of bloodstream infection(BSI) .Methods The serum levels of PCT and hs-CRP of 58 BSI patients(test group) and 58 non BSI patients(control group) were detected .The early diagnosis value of PCT and hs-CRP was evaluated by ROC curve .Results There were significant difference between the serum PCT and hs-CRP levels of test group and control group(P<0 .05) .The ROC AUC of PCT and hs-CRP were 0 .902(95% CI:0 .850-0 .955) and 0 .706(95% CI:0 .611-0 .801) ,respectively . With 2 .24 ng/mL being the diagnostic cut-off value ,the diagnostic sensitivity ,specificity ,positive predictive value ,and negative pre-dictive value of PCT were 77 .6% ,91 .4% ,90 .0% ,and 80 .3% ,respectively .With 64 .83 mg/L being the diagnostic cut-off value ,the di-agnostic sensitivity ,specificity ,positive predictive value ,and negative predictive value of hs-CRP were 74 .1% ,62 .1% ,54 .4% ,and 59 .5% , respectively .Conclusion Detection of serum PCT and hs-CRP has important clinical value in early diagnosis of BSI .