CAJ | 학술논문

目的：探讨高血压患者血清胱抑素C（CysC）和N端脑钠肽前体（NT-proBNP）水平的变化。方法选取89例高血压患者并分为5个亚组：A组（20例），单纯性高血压组；B组（18例），高血压合并左心肥厚组；C组（15例），高血压合并心力衰竭组；D组（17例），高血压合并早期肾功能损害组；E组（19例），高血压合并冠心病组。并选取20例健康体检者作为对照组，测定各组血清CysC和NT-proBNP水平。结果 B、C、D组的CysC水平高于对照组，E组CysC水平低于对照组，差异均有统计学意义（P＜0．05）。D组的NT-proBNP水平高于对照组（P＜0．05），B、C、E组NT-proBNP水平显著高于对照组（P＜0．01），差异均有统计学意义。结论测定高血压患者血清CysC和NT-proBNP水平可以了解病情的发展及合并疾病发生情况，为临床治疗提供依据。
목적：탐토고혈압환자혈청광억소C（CysC）화N단뇌납태전체（NT-proBNP）수평적변화。방법선취89례고혈압환자병분위5개아조：A조（20례），단순성고혈압조；B조（18례），고혈압합병좌심비후조；C조（15례），고혈압합병심력쇠갈조；D조（17례），고혈압합병조기신공능손해조；E조（19례），고혈압합병관심병조。병선취20례건강체검자작위대조조，측정각조혈청CysC화NT-proBNP수평。결과 B、C、D조적CysC수평고우대조조，E조CysC수평저우대조조，차이균유통계학의의（P＜0．05）。D조적NT-proBNP수평고우대조조（P＜0．05），B、C、E조NT-proBNP수평현저고우대조조（P＜0．01），차이균유통계학의의。결론측정고혈압환자혈청CysC화NT-proBNP수평가이료해병정적발전급합병질병발생정황，위림상치료제공의거。
Objective To investigate the changes of serum levels of CysC and NT-proBNP in patients with hypertension .Meth-ods 89 patients with hypertension were selected and divided into five subgroups:Group A (n= 20) with simple hypertension;Group B(n=18) with hypertension and left ventricular hypertrophy ;Group C(n=15) with hypertension and heart failure;Group D(n=17) with hypertension and early renal damage;Group D(n=19) with hypertension and coronary heart disease .20 healthy in-dividuals were selected as control group .The serum levels of CysC and NT-proBNP were measured in all the groups .Results The serum levels of CysC in group B ,C and D were higher than control group (P<0 .05) ,and serum CysC level in group E was lower than control group(P<0 .05) .The serum level of NT-proBNP in group D was higher than control group(P<0 .05) ,and the serum NT-proBNP levels in group B ,C and E were significantly higher than control group (P<0 .01) .Conclusion The detection of CysC and NT-proBNP in patients with hypertension is helpful for understanding the progression of the disease and the occurrence of amalgamative diseases ,and it provides positive proof for clinical treatment .