国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
21期
2883-2884
,共2页
D-二聚体%C反应蛋白%肝硬化%腹膜炎
D-二聚體%C反應蛋白%肝硬化%腹膜炎
D-이취체%C반응단백%간경화%복막염
D-dimer%C-reactive protein%cirrhosis%peritonitis
目的:了解血浆D-二聚体(D-D)浓度在肝硬化腹腔积液患者自发性细菌性腹膜炎(SBP)诊断中的应用价值。方法留取肝硬化腹腔积液患者137例,分为SBP组和非自发性细菌性腹膜炎(NSBP)组,另选取慢性肝病患者30例(慢性肝病组)及30例健康者(健康对照组),分别测定各组D-D和C反应蛋白(CRP)浓度。结果 SBP组、NSBP组、慢性肝病组、健康对照组D-D浓度分别为(7.82±5.68)、(5.55±4.55)、(0.45±0.26)、(0.06±0.04)mg/L ;血清CRP分别为(30.0±29.6)、(16.4±20.5)、(5.3±1.8)、(2.1±0.9)mg/L。SBP组和NSBP组D-D、CRP浓度均明显高于慢性肝病组和健康对照组(P<0.01)。SBP组D-D、CRP浓度高于NSBP组,差异也有统计学意义(P<0.05)。ROC曲线分析显示,D-D诊断SBP的曲线下面积、灵敏度、特异度分别为0.650、0.604、0.709;CRP分别为0.705、0.792、0.582。结论检测D-D有助于肝硬化腹腔积液患者SBP的早期诊断。
目的:瞭解血漿D-二聚體(D-D)濃度在肝硬化腹腔積液患者自髮性細菌性腹膜炎(SBP)診斷中的應用價值。方法留取肝硬化腹腔積液患者137例,分為SBP組和非自髮性細菌性腹膜炎(NSBP)組,另選取慢性肝病患者30例(慢性肝病組)及30例健康者(健康對照組),分彆測定各組D-D和C反應蛋白(CRP)濃度。結果 SBP組、NSBP組、慢性肝病組、健康對照組D-D濃度分彆為(7.82±5.68)、(5.55±4.55)、(0.45±0.26)、(0.06±0.04)mg/L ;血清CRP分彆為(30.0±29.6)、(16.4±20.5)、(5.3±1.8)、(2.1±0.9)mg/L。SBP組和NSBP組D-D、CRP濃度均明顯高于慢性肝病組和健康對照組(P<0.01)。SBP組D-D、CRP濃度高于NSBP組,差異也有統計學意義(P<0.05)。ROC麯線分析顯示,D-D診斷SBP的麯線下麵積、靈敏度、特異度分彆為0.650、0.604、0.709;CRP分彆為0.705、0.792、0.582。結論檢測D-D有助于肝硬化腹腔積液患者SBP的早期診斷。
목적:료해혈장D-이취체(D-D)농도재간경화복강적액환자자발성세균성복막염(SBP)진단중적응용개치。방법류취간경화복강적액환자137례,분위SBP조화비자발성세균성복막염(NSBP)조,령선취만성간병환자30례(만성간병조)급30례건강자(건강대조조),분별측정각조D-D화C반응단백(CRP)농도。결과 SBP조、NSBP조、만성간병조、건강대조조D-D농도분별위(7.82±5.68)、(5.55±4.55)、(0.45±0.26)、(0.06±0.04)mg/L ;혈청CRP분별위(30.0±29.6)、(16.4±20.5)、(5.3±1.8)、(2.1±0.9)mg/L。SBP조화NSBP조D-D、CRP농도균명현고우만성간병조화건강대조조(P<0.01)。SBP조D-D、CRP농도고우NSBP조,차이야유통계학의의(P<0.05)。ROC곡선분석현시,D-D진단SBP적곡선하면적、령민도、특이도분별위0.650、0.604、0.709;CRP분별위0.705、0.792、0.582。결론검측D-D유조우간경화복강적액환자SBP적조기진단。
Objective To investigate the application value of plasma D-dimer(D-D )in the diagnosis of spontaneous bacterial per-itonitis(SBP)in patients with liver cirrhosis .Methods 137 cases of cirrhotic patients with ascites were selected and divided into SBP group and non SBP(NSBP) group .30 cases of patients with chronic liver disease and 30 healthy individuals were selected as chronic liver disease group and normal control group ,respectively .The levels of D-D and C-reactive protein(CRP) were measured in specimens from all the groups .Results The D-D levels of SBP group ,NSBP group ,chronic liver disease group and normal control group were (7 .82 ± 5 .68) ,(5 .55 ± 4 .55) ,(0 .45 ± 0 .26) and (0 .06 ± 0 .04) mg/L ,respectively .And the serum CRP levels were (30 .0 ± 29 .6) ,(16 .4 ± 20 .5) ,(5 .3 ± 1 .8) and (2 .1 ± 0 .9)mg/L ,respectively .The levels of D-D and CRP were both higher in SBP group and NSBP group than in chronic liver disease group and normal control group(P<0 .01) .The D-D and CRP levels of SBP group were both significantly higher than those of NSBP group (P<0 .05) .The ROC curve showed that the AUC ,sensitivity and specificity of D-D were 0 .650 ,0 .604 and 0 .709 ,respectively ,and those of CRP were 0 .705 ,0 .792 and 0 .582 ,respectively .Conclu-sion Plasma D-D detection was beneficial to the early diagnosis of SBP in cirrhotic patients with ascites .