CAJ | 학술논문

目的：探讨MicroRNA合成通路相关基因Dicer基因rs1057035 T＞C多态性与肿瘤易感性的关系。方法根据关键词全面搜索中英文数据库，依据纳入和排除标准筛选合适文献并提取所需数据，用RevM an5．1软件对数据进行合并分析，计算合并的优势比（OR）及其95％置信区间（95％ C I）。结果经筛选总共纳入10篇与Dicer基因多态性与肿瘤易感性相关的病例对照研究，meta分析结果显示Dicer基因3′端非编码区多态性位点 rs1057035突变碱基C能够降低肿瘤的罹患风险，OR＝0．92，95％ C I为0．87～0．97，P＝0．003。结论 Dicer基因rs1057035 T＞C可能与肿瘤的易感性存在相关性。
목적：탐토MicroRNA합성통로상관기인Dicer기인rs1057035 T＞C다태성여종류역감성적관계。방법근거관건사전면수색중영문수거고，의거납입화배제표준사선합괄문헌병제취소수수거，용RevM an5．1연건대수거진행합병분석，계산합병적우세비（OR）급기95％치신구간（95％ C I）。결과경사선총공납입10편여Dicer기인다태성여종류역감성상관적병례대조연구，meta분석결과현시Dicer기인3′단비편마구다태성위점 rs1057035돌변감기C능구강저종류적리환풍험，OR＝0．92，95％ C I위0．87～0．97，P＝0．003。결론 Dicer기인rs1057035 T＞C가능여종류적역감성존재상관성。
Objective To investigate the association between a genetic variant in Dicer and cancer risk .Methods Both English and Chi-nese databases were carefully searched comprehensively .Based on the including and excluding criteria ,literatures that were eligible were carefully screened and data were retrieved .Meta analysis was performed by RevMan 5 .1 software .Pooled odds ratios(OR) and 95% confi-dential interval(CI)were used for analysis .Results Ten eligible literatures were included in the meta analysis .Meta analysis showed that the mutant allele C in 3′untranslated region polymorphism loci rs1057035 of Dicer gene might reduce the cancer risk(OR=0 .92 ,95% CI=0 .87-0 .97 ,P=0 .003) .Conclusion The variant rs1057035 T>C in Dicer gene could be related to cancer susceptibility .