CAJ | 학술논문

目的：探讨不同孕期孕妇血清同型半胱氨酸（HCY）、叶酸、维生素B12水平与妊娠高血压综合征（PIH）之间的关系。方法选取一直在该院按期进行产检的539例孕妇为研究对象（其中PIH 87例作为PIH组，其余452例产检正常作为正常妊娠组），分别于孕早期（孕8～10周、12～14周）、孕中期（孕18周、24周）、孕晚期（孕30周、36周）时空腹抽取孕妇血液测定血清HCY ，并检测叶酸、维生素B12水平，同时对研究对象补充服用叶酸、维生素B12情况以及PIH发病情况、胎儿出生缺陷情况进行询问、登记、核实。结果 PIH组与正常妊娠组相比较，孕中期及孕晚期血清 HCY水平明显升高（P＜0．05），在孕早期差异无统计学意义（P＞0．05）。在孕中期和孕晚期，PIH组与正常妊娠组血清 HCY水平与血清叶酸水平均呈明显的直线负相关关系（r＜0，P＜0．05），而与维生素B12水平无相关性（P＞0．05）。结论孕中期及孕晚期，孕妇血清 HCY水平升高，其 PIH风险明显增加。
목적：탐토불동잉기잉부혈청동형반광안산（HCY）、협산、유생소B12수평여임신고혈압종합정（PIH）지간적관계。방법선취일직재해원안기진행산검적539례잉부위연구대상（기중PIH 87례작위PIH조，기여452례산검정상작위정상임신조），분별우잉조기（잉8～10주、12～14주）、잉중기（잉18주、24주）、잉만기（잉30주、36주）시공복추취잉부혈액측정혈청HCY ，병검측협산、유생소B12수평，동시대연구대상보충복용협산、유생소B12정황이급PIH발병정황、태인출생결함정황진행순문、등기、핵실。결과 PIH조여정상임신조상비교，잉중기급잉만기혈청 HCY수평명현승고（P＜0．05），재잉조기차이무통계학의의（P＞0．05）。재잉중기화잉만기，PIH조여정상임신조혈청 HCY수평여혈청협산수평균정명현적직선부상관관계（r＜0，P＜0．05），이여유생소B12수평무상관성（P＞0．05）。결론잉중기급잉만기，잉부혈청 HCY수평승고，기 PIH풍험명현증가。
Objective To study on the relationship between the levels of homocysteine(HCY) ,folic acid and vitamin B12 and pregnancy-induced hypertension(PIH) in different pregnancies .Methods 539 pregnant women who registered for prenatal exami-nation of pregnant in the hospital were selected as research subjects .And there were 87 cases of PIH(PIH group) and 452 cases of normal pregnancy(normal pregnancy group) among them .The fasting blood samples were collected respectively in early pregnancy (8-10 weeks and 12-14 weeks of pregnancy) ,mid pregnancy(18 pregnancy weeks and 24 pregnancy weeks) ,and late pregnancy (30 pregnancy weeks and 36 pregnancy weeks) ,and the levels of HCY ,folic acid and vitamin B12 were measured .At the same time ,the supplements of folic acid and vitamin B12 and the incidence of PIH and birth defects were asked ,registered and checked . Results Compared with normal pregnancy group ,the serum HCY level of PIH group significantly increased in medium and late pregnancy periods (P<0 .05) ,and had no statistical significance in early pregnancy(P>0 .05) .In mid and late pregnancy periods , the serum HCY levels of PIH group and normal pregnant group negatively correlated with serum folic acid levels (r<0 ,P<0 .05) , and did not correlate with vitamin B12 levels (P>0 .05) .Conclusion In middle and late pregnancy periods ,if the serum HCY level of pregnant women increased ,the risk of PIH increased significantly .