CAJ | 학술논문

本研究在不加入表面活性剂条件下采用快速沉淀法制备盐酸吡格列微粉，分别利用扫描电镜( SEM )、X射线衍射( XRD)、红外光谱分析( FT-IR)等分析方法对原药及产品的性质进行了表征。SEM分析表明，使用快速沉淀法制备的盐酸吡格列酮超微粉尺寸降低，粒度分布均匀，FT-IR、XRD分析表明，微粉化前后药物的化学结构并未发生改变，粒度明显减小，结晶度明显降低。
본연구재불가입표면활성제조건하채용쾌속침정법제비염산필격렬미분，분별이용소묘전경( SEM )、X사선연사( XRD)、홍외광보분석( FT-IR)등분석방법대원약급산품적성질진행료표정。SEM분석표명，사용쾌속침정법제비적염산필격렬동초미분척촌강저，립도분포균균，FT-IR、XRD분석표명，미분화전후약물적화학결구병미발생개변，립도명현감소，결정도명현강저。
The microsized pioglitazone hydrochloride(PH) was prepared via the rapid precipitation proces without surfactant. The microsized pioglitazone hydrochloride and the raw drug were well characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), fourier transform infrared spectrometry (FT-IR). The study indicated that after micronization, the particle size decreased, the range of particle size distribution became well through SEM. FT-IR and XRD analysis indicated the particle size decreased and ccrystallinity decreased during the process and no change in chemical group structure.