中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
21期
3284-3286
,共3页
肺心病%法舒地尔%硫化氢%心钠素
肺心病%法舒地爾%硫化氫%心鈉素
폐심병%법서지이%류화경%심납소
Pulmonary Heart Disease%Fasudil%Hydrogen sulfide%Atrial B-type Natriuretic Factor
目的：探讨法舒地尔对慢性肺源性心脏病血浆硫化氢（H2S）和N末端B型脑钠肽（NT-proBNP）的影响。方法102例慢性肺心病患者按照数字表法随机分为观察组和对照组，各51例。对照组采用常规治疗，观察组在常规治疗的基础上加用法舒地尔，两组共治疗14 d。治疗前后测定患者的平均肺动脉压力（MPAP），血浆H2S和NT-proBNP。结果治疗后观察组总有效率为96．1％，高于对照组的86．3％（χ2＝4.046，P＜0．05）。两组治疗后MPAP均明显下降，且观察组比对照组下降更明显（t＝7．246，P＜0．05）。治疗后两组血浆H2S均有明显升高，且观察组升高更明显（t＝2．856，P＜0．05），两组治疗后血浆NT-proBNP均有明显降低，且观察组降低更明显（t＝10．706，P＜0．05）。结论法舒地尔可以明显改善慢性肺源性心脏病患者血浆H2 S和NT-proBNP。
目的：探討法舒地爾對慢性肺源性心髒病血漿硫化氫（H2S）和N末耑B型腦鈉肽（NT-proBNP）的影響。方法102例慢性肺心病患者按照數字錶法隨機分為觀察組和對照組，各51例。對照組採用常規治療，觀察組在常規治療的基礎上加用法舒地爾，兩組共治療14 d。治療前後測定患者的平均肺動脈壓力（MPAP），血漿H2S和NT-proBNP。結果治療後觀察組總有效率為96．1％，高于對照組的86．3％（χ2＝4.046，P＜0．05）。兩組治療後MPAP均明顯下降，且觀察組比對照組下降更明顯（t＝7．246，P＜0．05）。治療後兩組血漿H2S均有明顯升高，且觀察組升高更明顯（t＝2．856，P＜0．05），兩組治療後血漿NT-proBNP均有明顯降低，且觀察組降低更明顯（t＝10．706，P＜0．05）。結論法舒地爾可以明顯改善慢性肺源性心髒病患者血漿H2 S和NT-proBNP。
목적：탐토법서지이대만성폐원성심장병혈장류화경（H2S）화N말단B형뇌납태（NT-proBNP）적영향。방법102례만성폐심병환자안조수자표법수궤분위관찰조화대조조，각51례。대조조채용상규치료，관찰조재상규치료적기출상가용법서지이，량조공치료14 d。치료전후측정환자적평균폐동맥압력（MPAP），혈장H2S화NT-proBNP。결과치료후관찰조총유효솔위96．1％，고우대조조적86．3％（χ2＝4.046，P＜0．05）。량조치료후MPAP균명현하강，차관찰조비대조조하강경명현（t＝7．246，P＜0．05）。치료후량조혈장H2S균유명현승고，차관찰조승고경명현（t＝2．856，P＜0．05），량조치료후혈장NT-proBNP균유명현강저，차관찰조강저경명현（t＝10．706，P＜0．05）。결론법서지이가이명현개선만성폐원성심장병환자혈장H2 S화NT-proBNP。
Objective To explore the influence of fasudil on plasma hydrogen sulfide(H2S)and N-terminal B-type natriuretic peptide( NT-proBNP) in patients with chronic pulmonary heart disease.Methods According to the digital table,102 patients with chronic pulmonary heart disease were randomly divided into the observation group and the control group, each group in 51 cases.The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated through the conventional treatment plus fasudil. They were treated for 14 days.The mean pulmonary artery pressure( MPAP) ,plasma H2 S and NT-proBNP were detec-ted.Results After treatment,the total effective rate in the observation group was 96.1%,which was higher than 86.3%in the control group(χ2 =4.046,P<0.05).MPAP in the two groups of patients were significantly decreased, and the observation group decreased more significantly than the control group(t=7.246,P<0.05).After treatment, plasma H2S were significantly higher,and the observation group increased more significantly(t=2.856,P<0.05), plasma NT-proBNP in two groups after treatment were significantly reduced,and the observation group decreased sig-nificantly(t=10.706,P<0.05).Conclusion Fasudil can be significantly improved plasma H2S and NT-proBNP in patients with chronic pulmonary heart disease.
