CAJ | 학술논문

目的：了解恶性骨肿瘤患者化疗间歇期的睡眠障碍和生活质量情况，以及睡眠障碍与生活质量的相关关系。方法使用匹兹堡睡眠质量指数，欧洲癌症研究与治疗组织生活质量核心问卷对120例在广州市某三级甲等医院进行化疗的骨肿瘤患者进行问卷调查。结果恶性骨肿瘤患者化疗间歇期睡眠障碍评分（8.44±3.67）分，有55.8%的患者存在睡眠障碍。患者生活质量明显低于常模，除认知功能、气促、便秘和腹泻4个条目外，其余两组比较差异有统计学意义（P<0.05），但总体生活质量优于住院患者，除社会功能、便秘和腹泻3个条目外，其余两组比较差异有统计学意义（P<0.05）。生活质量的各功能维度得分与睡眠障碍得分呈负相关（P<0.01），症状维度中，除恶心与呕吐和腹泻外，其余各症状得分与生活质量呈正相关（P<0.01）。结论骨肿瘤患者化疗间歇期生活质量较差，且普遍存在睡眠障碍症状，睡眠障碍越严重，患者生活质量越差。因此提示医护人员要关注患者的睡眠质量，分析导致睡眠障碍的原因，提出干预措施，从而提高化疗患者的生活质量。
목적：료해악성골종류환자화료간헐기적수면장애화생활질량정황，이급수면장애여생활질량적상관관계。방법사용필자보수면질량지수，구주암증연구여치료조직생활질량핵심문권대120례재엄주시모삼급갑등의원진행화료적골종류환자진행문권조사。결과악성골종류환자화료간헐기수면장애평분（8.44±3.67）분，유55.8%적환자존재수면장애。환자생활질량명현저우상모，제인지공능、기촉、편비화복사4개조목외，기여량조비교차이유통계학의의（P<0.05），단총체생활질량우우주원환자，제사회공능、편비화복사3개조목외，기여량조비교차이유통계학의의（P<0.05）。생활질량적각공능유도득분여수면장애득분정부상관（P<0.01），증상유도중，제악심여구토화복사외，기여각증상득분여생활질량정정상관（P<0.01）。결론골종류환자화료간헐기생활질량교차，차보편존재수면장애증상，수면장애월엄중，환자생활질량월차。인차제시의호인원요관주환자적수면질량，분석도치수면장애적원인，제출간예조시，종이제고화료환자적생활질량。
Objective To assess the sleep disturbance and quality of life (QOL) in patients with bone tumors during chemotherapy intermission. Methods A total of 120 patients were recruited from a Class III Grade I hospital in Guangzhou in this study. Sleep disturbance and QOL were respectively evaluated by Pittsburgh sleep quality index (PSQI) and European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30 (EORTC-QLQ-C30). Results The mean score of QOL of patients was significantly lower than that of the general population in Asia but higher than that of hospitalized patients (P<0.05). The mean score of sleep disturbance was 8.44±3.67 and the patients with sleep disturbance had lower scores in function domains but had higher scores in symptom domains (P<0.05). Conclusion The quality of life in patients with malignant bone tumors during chemotherapy intermission is poor, and sleep disturbance is prevalent among the patients. There is negative correlation between QOL and sleep disturbance and targeted measures should be implemented to improve patients’ QOL.