CAJ | 학술논문

目的：观察卡托普利治疗急性胰腺炎的疗效及对血清C反应蛋白（CRP）的影响。方法选择100例急性胰腺炎患者按照随机数字表法分为对照组和观察组，每组各50例，对照组给予禁食、抗炎、胃肠减压、生长抑素等常规治疗，观察组在给予常规治疗的基础上再给予卡托普利治疗，比较两组患者治疗7d有效率、疼痛缓解时间、淀粉酶恢复正常时间、胰腺水肿改善时间及治疗前后血清CRP情况。结果观察组治疗7 d有效率为86％，明显高于对照组的72％，两组比较差异有统计学意义（χ2＝7．334，P＜0．05）；观察组患者治疗后疼痛缓解时间、淀粉酶恢复正常时间、胰腺水肿改善时间分别为（1．75±0．44） d、（3．49±1．22） d、（7.50±2．39）d，对照组为（2．25±0．58）d、（4．25±1．59）d、（9．25±2．87）d，两组差异均有统计学意义（t1＝3．55，t2＝4．18，t3＝8．33，均P＜0．05）；观察组治疗后血清CRP水平为（10．39±3．66） mg/L，较对照组的（25.46±8．33）mg/L改善明显，两组间差异有统计学意义（t＝11．45，P＜0．05）。结论卡托普利治疗急性胰腺炎具有较好的效果，能有效改善血清CRP水平。
목적：관찰잡탁보리치료급성이선염적료효급대혈청C반응단백（CRP）적영향。방법선택100례급성이선염환자안조수궤수자표법분위대조조화관찰조，매조각50례，대조조급여금식、항염、위장감압、생장억소등상규치료，관찰조재급여상규치료적기출상재급여잡탁보리치료，비교량조환자치료7d유효솔、동통완해시간、정분매회복정상시간、이선수종개선시간급치료전후혈청CRP정황。결과관찰조치료7 d유효솔위86％，명현고우대조조적72％，량조비교차이유통계학의의（χ2＝7．334，P＜0．05）；관찰조환자치료후동통완해시간、정분매회복정상시간、이선수종개선시간분별위（1．75±0．44） d、（3．49±1．22） d、（7.50±2．39）d，대조조위（2．25±0．58）d、（4．25±1．59）d、（9．25±2．87）d，량조차이균유통계학의의（t1＝3．55，t2＝4．18，t3＝8．33，균P＜0．05）；관찰조치료후혈청CRP수평위（10．39±3．66） mg/L，교대조조적（25.46±8．33）mg/L개선명현，량조간차이유통계학의의（t＝11．45，P＜0．05）。결론잡탁보리치료급성이선염구유교호적효과，능유효개선혈청CRP수평。
Objective To evaluate the effect of captopril in treatment of acute pancreatitis and its influence on serum C reactive protein ( CRP) .Methods 100 cases of acute pancreatitis patients were randomly divided into the control group and observation group,50 cases in each group.The control group was treated with fasting,gastroin-testinal decompression,somatostatin, anti-inflammatory and other conventional treatment, while the observation group was given captopril on basis of routine treatment,the effective rate after 7 days of treatment,pain relief time,amylase returned to normal time,pancreatic edema improved time,serum CRP before and after treatment were compared be-tween the two groups of patients.Results The effective rate after 7 days of treatment of the observation group was 86%,which was significantly higher than 72%of the control group(χ2 =7.334,P<0.05);The pain relief time,am-ylase returned to normal time,pancreatic edema improved time of the observation group after treatment were (1.75 ± 0.44)d,(3.49 ±1.22)d,(7.50 ±2.39)d,respectively,which of the control group were (2.25 ±0.58)d,(4.25 ± 1.59)d,(9.25 ±2.87)d,respectively,there were statistically significant difference between the two groups(t1 =3.55,t2 =4.18,t3 =8.33,all P<0.05);the serum CRP level of the observation group after treatment was (10.39 ± 3.66)mg/L,improved obviously compared to (25.46 ±8.33)mg/L of the control group,the differences between the two groups was statistically significant(t=11.45,P<0.05).Conclusion Captopril has a good effect in treatment of acute pancreatitis,which can effectively improve the level of serum CRP.