CAJ | 학술논문

目的：探讨斯氏普罗威登菌的医院感染状态及耐药特点，为临床治疗提供帮助。方法回顾性分析76例感染病例的标本来源、科室分布及抗生素药敏情况。结果76例标本主要来源于痰液（71.1％）、伤口分泌物（10．5％）和血液（6．6％）；感染科室主要为重症监护室（40．8％）、呼吸内科（9．2％）和普通外科（7．9％）；该菌耐药情况较严重，多重耐药（MDR）株占65．8％，泛耐药（PDR）株占26．3％，泛耐药株感染患者病死率（45．0％）显著高于非泛耐药患者（5．8％），耐药率较低的抗生素分别是亚胺培南、氟喹诺酮类和阿米卡星等，亚胺培南耐药率最低（31．5％）。结论斯氏普罗威登菌多重耐药现象严重，治疗首选亚胺培南，次选氟喹诺酮类或氨基糖苷类抗生素，对该菌引起的医院感染应加强感染监控。
목적：탐토사씨보라위등균적의원감염상태급내약특점，위림상치료제공방조。방법회고성분석76례감염병례적표본래원、과실분포급항생소약민정황。결과76례표본주요래원우담액（71.1％）、상구분비물（10．5％）화혈액（6．6％）；감염과실주요위중증감호실（40．8％）、호흡내과（9．2％）화보통외과（7．9％）；해균내약정황교엄중，다중내약（MDR）주점65．8％，범내약（PDR）주점26．3％，범내약주감염환자병사솔（45．0％）현저고우비범내약환자（5．8％），내약솔교저적항생소분별시아알배남、불규낙동류화아미잡성등，아알배남내약솔최저（31．5％）。결론사씨보라위등균다중내약현상엄중，치료수선아알배남，차선불규낙동류혹안기당감류항생소，대해균인기적의원감염응가강감염감공。
Objective To study the distribution and drug resistance of clinical Providencia stuartii isolates and provide the basis data for clinical therapy.Methods A data analysis for the specimen source,the distribution of departments with infection and the antibiotic susceptibility results to 76 isolates was conducted in retrospectively. Results Among 76 strains were mainly from sputum (71.1%),wound secretions (10.5%) and blood (6.6%);the proportion of these strains from ICU was 40.8%,from respiratory department was 9.2%and from general surgery was 7.9%;The bacteria's drug resistance was more serious,multi drug resistant (MDR) strains accounted for 65.8%,pan drug resistant ( PDR) strains accounted for 26.3%,the mortality of patients with PDR strains infection was 45.0%,which was higher than 5.8%of no PDR strains infection.A low resistance rate of antibiotics were imipenem,fluoro-quinolones andamikacin,et al,and the rate of imipenem resistant was lowest(31.5%).Conclusion The multidrug resistance phenomenon of Providencia stuartii is serious, the first choice for the treatment is imipenem, the second choice was fluoroquinolones or amino glycopeptides antibiotics,the hospital infection caused by the bacterium infection in monitoring should be strengthened.