CAJ | 학술논문

目的：比较艾普拉唑和奥美拉唑三联疗法治疗幽门螺杆菌（ Hp ）阳性十二指肠球部溃疡的疗效。方法100例Hp阳性的十二指肠球部溃疡患者采用抽签法随机分为两组，分别给予艾普拉唑或奥美拉唑为基础的三联疗法治疗，5周后复查胃镜和13 C呼气试验，观察Hp根除率、1周和5周症状缓解率、溃疡愈合率和药物不良反应。结果艾普拉唑组和奥美拉唑组的Hp根除率分别为92％、78％（χ2＝3．853，P＜0.05）；溃疡愈合率分别为96％、90％（χ2＝1．561，P＞0．05）；治疗1周症状缓解率分别为92．3％、86．8％（上腹痛），89．7％、73．3％（反酸），88．9％、75．0％（烧灼感）；两组均未发现严重不良反应。结论艾普拉唑＋阿莫西林＋克林霉素三联疗法是根除Hp的理想方案。
목적：비교애보랍서화오미랍서삼련요법치료유문라간균（ Hp ）양성십이지장구부궤양적료효。방법100례Hp양성적십이지장구부궤양환자채용추첨법수궤분위량조，분별급여애보랍서혹오미랍서위기출적삼련요법치료，5주후복사위경화13 C호기시험，관찰Hp근제솔、1주화5주증상완해솔、궤양유합솔화약물불량반응。결과애보랍서조화오미랍서조적Hp근제솔분별위92％、78％（χ2＝3．853，P＜0.05）；궤양유합솔분별위96％、90％（χ2＝1．561，P＞0．05）；치료1주증상완해솔분별위92．3％、86．8％（상복통），89．7％、73．3％（반산），88．9％、75．0％（소작감）；량조균미발현엄중불량반응。결론애보랍서＋아막서림＋극림매소삼련요법시근제Hp적이상방안。
Objective To compare the clinical efficacy of ilaprazole standard triple therapy with omeprazole standard triple therapy in the treatment of patients with Helicobacter pylori ( Hp ) positive duodenal bulb ulcer. Methods 100 patients with Hp positive duodenal bulb ulcer were randomly divided into the two groups by lottery, given ilaprazole standard triple therapy and omeprazole standard triple therapy respectively.After 5 weeks of the course,take gastroscopy and the enzyme 13C-urea breath test,and the Hp eradication rate,clinical efficacy,ulcer heal-ing rate and adverse reactions were observed.Results The Hp eradication rate is better than the omeprazole group (92%vs 78%,χ2 =3.853,P<0.05),while the ulcer healing rate were no significant (96%vs 90%,χ2 =1.561, P>0.05).Conclusion It is a good method in the treatment of Hp positive duodenal bulb ulcer for ilaprazole stand-ard triple therapy.