CAJ | 학술논문

目的：探讨心肌炎患儿血清胰岛素样生长因子-1（IGF-1）水平变化及意义。方法选择50例心肌炎患儿，分别在急性期和恢复期抽取外周静脉血，用于IGF-1和CK-MB测定。选取参加健康体检的婴幼儿50例作为对照。 IGF-1用ELISA法测定， CK-MB 用电-化学发光法测定。结果患儿急性期 IGF-1为（22.90±9．30）mg/L，显著低于对照组及恢复期[（45．69±10．95）mg/L，（38．99±9．06）mg/L，均P＜0．01]， CK-MB为（77．48±8．71）mg/L，显著高于对照组及恢复期[（14．99±7．62）mg/L，（17．99±6．31）mg/L，均P＜0．01]。 IGF-1与CK-MB呈负相关（r＝-0．62，P＜0．01）。结论 IGF-1可能参与心肌炎心肌损伤修复过程，起保护作用。
목적：탐토심기염환인혈청이도소양생장인자-1（IGF-1）수평변화급의의。방법선택50례심기염환인，분별재급성기화회복기추취외주정맥혈，용우IGF-1화CK-MB측정。선취삼가건강체검적영유인50례작위대조。 IGF-1용ELISA법측정， CK-MB 용전-화학발광법측정。결과환인급성기 IGF-1위（22.90±9．30）mg/L，현저저우대조조급회복기[（45．69±10．95）mg/L，（38．99±9．06）mg/L，균P＜0．01]， CK-MB위（77．48±8．71）mg/L，현저고우대조조급회복기[（14．99±7．62）mg/L，（17．99±6．31）mg/L，균P＜0．01]。 IGF-1여CK-MB정부상관（r＝-0．62，P＜0．01）。결론 IGF-1가능삼여심기염심기손상수복과정，기보호작용。
Objective To investigate insulin-like growth factor-1(IGF-1) on the protective effect of infant myocarditis.Methods The serum levels of IGF-1 was detected by two-site enzyme-linked immunosorbent assy ( ELISA) and CK-MB by electrochemiluminescence at the acute and convalescent in 50 infant with myocarditis,and 50 normal healthy children as the controls.Results The serum levels of IGF-1 in acute myocarditis was significantly lower than those of healthy children and the convalescen[(22.90 ±9.30) mg/L vs (45.69 ±10.95) mg/L, (38.99 ±9.06)mg/L,all P<0.01],while the CK-MB was significantly higher than those of the control group and the convalescent[(77.48 ±8.71)mg/L vs (14.99 ±7.62)mg/L,(17.99 ±6.31)mg/L,all P<0.01.IGF-1 and CK-MB was negative correlation (r=-0.62,P<0.01).Conclusion IGF-1 is involved in the repair process of myocardial injury in myocarditis infant,and play some protective role in the mechanism.