CAJ | 학술논문

目的：研究血清淀粉样蛋白P（SAP）在3种常见结缔组织病患者血清中含量，探讨其在结缔组织病发生发展中的作用及意义。方法：用ELISA方法测定正常人、系统性红斑狼疮活动期和缓解期、类风湿关节炎活动期和缓解期、初治干燥综合征等风湿性疾病血清中血清淀粉样蛋白P（SAP）含量。统计各型患者血清中血清淀粉样蛋白P（SAP）的表达水平及其意义。结果：SAP在系统性红斑狼疮患者活动期血清中高表达，且其表达水平显著高于缓解期和正常人，差异均有统计学意义（P<0.05）。结论：血清淀粉样蛋白P（SAP）在系统性红斑狼疮活动期高表达，可以作为系统性红斑狼疮患者活动期的诊断指标之一。
목적：연구혈청정분양단백P（SAP）재3충상견결체조직병환자혈청중함량，탐토기재결체조직병발생발전중적작용급의의。방법：용ELISA방법측정정상인、계통성홍반랑창활동기화완해기、류풍습관절염활동기화완해기、초치간조종합정등풍습성질병혈청중혈청정분양단백P（SAP）함량。통계각형환자혈청중혈청정분양단백P（SAP）적표체수평급기의의。결과：SAP재계통성홍반랑창환자활동기혈청중고표체，차기표체수평현저고우완해기화정상인，차이균유통계학의의（P<0.05）。결론：혈청정분양단백P（SAP）재계통성홍반랑창활동기고표체，가이작위계통성홍반랑창환자활동기적진단지표지일。
Objective:To investigate the expression levels of Serum amyloid P(SAP)and its clinical significance in three common connective tissue diseases’ patients.Method:The expressions of SAP in serum were analyzed by enzyme linked immunosorbent assay(ELISA)in healthy persons,SLE patients with active disease and remission disease, rheumatoid arthritis patients with active disease and remission disease,sjogren’s syndrome with first treatment. Then statistical analysis was used for them.Result:SAP in patients with SLE activity has a high expression,and its expression level was significantly higher than that of remission and normal people,the differences were statistically significant (P<0.05).Conclusion:SAP is increased in SLE patients with active disease,and it can be used as one of the diagnostic index of the activity in SLE patients with active disease.