中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
30期
118-120
,共3页
卒中后抑郁%氟西汀%阿普唑仑%临床疗效
卒中後抑鬱%氟西汀%阿普唑崙%臨床療效
졸중후억욱%불서정%아보서륜%림상료효
Post-stroke depression%Fluoxetine%Alprazolam%Clinical efficacy
目的：观察氟西汀联合阿普唑仑治疗脑卒中后抑郁的临床疗效。方法：将2012年1月-2013年10月到本院精神科门诊就诊的脑卒中后抑郁患者按就诊顺序随机分为治疗组和对照组，每组40例。治疗组给予氟西汀联合阿普唑仑治疗，对照组给予黛力新联合多塞平治疗，疗程均为4周，随访3个月，从HAMD抑郁评估和临床神经功能缺损评分（MESSS）进行疗效评定。结果：治疗后，两组的HAMD抑郁总分与治疗前比较差异均有统计学意义（P<0.05），且治疗组更为明显；治疗后，两组的MESSS评分较治疗前均显著下降（P<0.01）；两组总有效率、不良反应比较差异均无统计学意义（P>0.05）。结论：氟西汀联合阿普唑仑治疗脑卒中后抑郁疗效显著，副作用小，值得临床推广应用。
目的：觀察氟西汀聯閤阿普唑崙治療腦卒中後抑鬱的臨床療效。方法：將2012年1月-2013年10月到本院精神科門診就診的腦卒中後抑鬱患者按就診順序隨機分為治療組和對照組，每組40例。治療組給予氟西汀聯閤阿普唑崙治療，對照組給予黛力新聯閤多塞平治療，療程均為4週，隨訪3箇月，從HAMD抑鬱評估和臨床神經功能缺損評分（MESSS）進行療效評定。結果：治療後，兩組的HAMD抑鬱總分與治療前比較差異均有統計學意義（P<0.05），且治療組更為明顯；治療後，兩組的MESSS評分較治療前均顯著下降（P<0.01）；兩組總有效率、不良反應比較差異均無統計學意義（P>0.05）。結論：氟西汀聯閤阿普唑崙治療腦卒中後抑鬱療效顯著，副作用小，值得臨床推廣應用。
목적：관찰불서정연합아보서륜치료뇌졸중후억욱적림상료효。방법：장2012년1월-2013년10월도본원정신과문진취진적뇌졸중후억욱환자안취진순서수궤분위치료조화대조조，매조40례。치료조급여불서정연합아보서륜치료，대조조급여대력신연합다새평치료，료정균위4주，수방3개월，종HAMD억욱평고화림상신경공능결손평분（MESSS）진행료효평정。결과：치료후，량조적HAMD억욱총분여치료전비교차이균유통계학의의（P<0.05），차치료조경위명현；치료후，량조적MESSS평분교치료전균현저하강（P<0.01）；량조총유효솔、불량반응비교차이균무통계학의의（P>0.05）。결론：불서정연합아보서륜치료뇌졸중후억욱료효현저，부작용소，치득림상추엄응용。
Objective:To observe the clinical efficacy of Fluoxetine combined with Alprazolam on post-stroke depression.Method:80 patients with depression after stroke from January 2012 to October 2013 in our hospital psychiatric outpatient were randomly divided into two groups,the treatment group and the control group,40 patients in each group. The treatment group was given Fluoxetine combined with Alprazolam to treatment,and the control group was given Deanxit combined with Doxepin to treatment. The efficacy was evaluated by the HAMD and MESSS score.Result:After treatment, HAMD depression scores of two groups were statistically significant differences which compared with before treatment, and the treatment group was more obvious(P<0.05);after treatment,MESSS score of two groups compared with before treatment were significantly decreased(P<0.01). The total effective rate,adverse reaction between the two groups had no statistical significance(P>0.05).Conclusion:The clinical efficacy of Fluoxetine combined with Alprazolam on post-stroke depression is very significant,and the side effect is seldomly,it is one method which is worth to popularize.
