CAJ | 학술논문

目的：研究贝伐单抗治疗脑转移放疗后坏死（RN）的效果。方法：回顾性分析脑转移放疗后坏死患者14例的临床资料，所有患者均接受贝伐单抗治疗10~15 mg/（kg·2周）。比较治疗前后RN的MRI图像改变情况和临床症状的观察。结果：贝伐单抗治疗后第1次随访相对于治疗前的RN平均体积在MRI钆增强T1加权图像和磁共振成像液体衰减反转恢复序列（FLAIR）图像中缩小分别为67.8%和63.3%；第2次随访为66.8%和67.3%；远期随访缩小52.2%和增加56.7%。第1次随访和第2次随访与治疗前比较差异有统计学意义（P<0.05）。所有患者在接受贝伐单抗治疗后均开始皮质醇减量治疗，其中13例患者RN相关症状均有改善并较为稳定，均未出现颅内出血或其他副作用。结论：贝伐单抗用于治疗脑转移RN临床效果明显，并能减少皮质醇用量。
목적：연구패벌단항치료뇌전이방료후배사（RN）적효과。방법：회고성분석뇌전이방료후배사환자14례적림상자료，소유환자균접수패벌단항치료10~15 mg/（kg·2주）。비교치료전후RN적MRI도상개변정황화림상증상적관찰。결과：패벌단항치료후제1차수방상대우치료전적RN평균체적재MRI구증강T1가권도상화자공진성상액체쇠감반전회복서렬（FLAIR）도상중축소분별위67.8%화63.3%；제2차수방위66.8%화67.3%；원기수방축소52.2%화증가56.7%。제1차수방화제2차수방여치료전비교차이유통계학의의（P<0.05）。소유환자재접수패벌단항치료후균개시피질순감량치료，기중13례환자RN상관증상균유개선병교위은정，균미출현로내출혈혹기타부작용。결론：패벌단항용우치료뇌전이RN림상효과명현，병능감소피질순용량。
Objective:To research the effect of treatment of brain metastasis radionecrosis(RN)with beacizumab. Method:The clinical data of 14 brain metastasis patients who were all treated by 10-15mg/(kg·2w)beacizumab after diagnosed radionecrosis were retrospectively analyzed. The MRI image variation before and after the treatment with bevacizumab were compared.Result:Compared with before treatment of RN,the average volume of first follow-up decrease 67.8%and 63.3%in MRI T1-weighted image and MRI fluid attenuated inversion recovery(FLAIR)image.In the second follow-up,outcome were decreased 66.8%and 67.3%respectively. Long-term follow-up showed 52.2%decreased and 56.7%increased respectively. The using of cortisol was lower than before. The first and second follow-up compared with before treatment,the difference was statistically significant(P<0.05). The symptoms of 13 patients had improved and became stable. All did not appear intracranial hemorrhage or other side effects.Conclusion:Beacizumab obviously improved local control and quality of life in patient with RN of brain metastasis,and also decreased the dose of cortisol.