中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
30期
45-47
,共3页
赵晶伟%王保永%周晓峰%季青
趙晶偉%王保永%週曉峰%季青
조정위%왕보영%주효봉%계청
缬沙坦%苯磺酸左旋氨氯地平%慢性肾小球肾炎
纈沙坦%苯磺痠左鏇氨氯地平%慢性腎小毬腎炎
힐사탄%분광산좌선안록지평%만성신소구신염
Valsartan%Levamlodipine besylate%Chronic glomerulonephritis
目的：观察缬沙坦胶囊联合小剂量苯磺酸左旋氨氯地平治疗慢性肾小球肾炎的临床效果。方法：选取2011年3月-2013年10月本院住院及门诊治疗的60例慢性肾小球肾炎患者，按照随机数字表法将其分为治疗组和对照组各30例。对照组给予缬沙坦口服，治疗组在对照组治疗基础上同时加用小剂量苯磺酸左旋氨氯地平2.5~5.0 mg/d，疗程12周，观察比较两组患者的治疗效果、治疗前后的血压及尿素氮、血肌酐及尿蛋白定量的变化。结果：治疗组的治疗总有效率96.7%（29/30）明显高于对照组的53.3%（16/30），差异有统计学意义（P<0.05）。与治疗前比较，两组治疗后24 h尿蛋白定量均有明显降低，且治疗组的尿蛋白定量明显低于对照组，差异均有统计学意义（P<0.05），而两组治疗前后的尿素氮、血肌酐均未见明显改变，不良反应也均未见明显差异（P>0.05）。结论：缬沙坦联合小剂量苯磺酸左旋氨氯地平治疗慢性肾小球肾炎疗效显著，且无严重不良反应，值得临床推广。
目的：觀察纈沙坦膠囊聯閤小劑量苯磺痠左鏇氨氯地平治療慢性腎小毬腎炎的臨床效果。方法：選取2011年3月-2013年10月本院住院及門診治療的60例慢性腎小毬腎炎患者，按照隨機數字錶法將其分為治療組和對照組各30例。對照組給予纈沙坦口服，治療組在對照組治療基礎上同時加用小劑量苯磺痠左鏇氨氯地平2.5~5.0 mg/d，療程12週，觀察比較兩組患者的治療效果、治療前後的血壓及尿素氮、血肌酐及尿蛋白定量的變化。結果：治療組的治療總有效率96.7%（29/30）明顯高于對照組的53.3%（16/30），差異有統計學意義（P<0.05）。與治療前比較，兩組治療後24 h尿蛋白定量均有明顯降低，且治療組的尿蛋白定量明顯低于對照組，差異均有統計學意義（P<0.05），而兩組治療前後的尿素氮、血肌酐均未見明顯改變，不良反應也均未見明顯差異（P>0.05）。結論：纈沙坦聯閤小劑量苯磺痠左鏇氨氯地平治療慢性腎小毬腎炎療效顯著，且無嚴重不良反應，值得臨床推廣。
목적：관찰힐사탄효낭연합소제량분광산좌선안록지평치료만성신소구신염적림상효과。방법：선취2011년3월-2013년10월본원주원급문진치료적60례만성신소구신염환자，안조수궤수자표법장기분위치료조화대조조각30례。대조조급여힐사탄구복，치료조재대조조치료기출상동시가용소제량분광산좌선안록지평2.5~5.0 mg/d，료정12주，관찰비교량조환자적치료효과、치료전후적혈압급뇨소담、혈기항급뇨단백정량적변화。결과：치료조적치료총유효솔96.7%（29/30）명현고우대조조적53.3%（16/30），차이유통계학의의（P<0.05）。여치료전비교，량조치료후24 h뇨단백정량균유명현강저，차치료조적뇨단백정량명현저우대조조，차이균유통계학의의（P<0.05），이량조치료전후적뇨소담、혈기항균미견명현개변，불량반응야균미견명현차이（P>0.05）。결론：힐사탄연합소제량분광산좌선안록지평치료만성신소구신염료효현저，차무엄중불량반응，치득림상추엄。
Objective:To observe the clinical effect of the Valsartan capsules combined with low-dose Levamlodipine besylate in treatment of chronic glomerulonephritis.Method:60 chronic glomerulonephritis patients in the inpatient and outpatient of our hospital from March 2011 to October 2013 were selected,they were divided into the treatment group and the control group according to the random number table method,30 cases in each group.The control group was given valsartan oral for 12 weeks,at the same time the treatment group was given low-dose Levamlodipine besylate 2.5-5.0 mg/d on the basis of control group therapy.The treatment effect and the changes of blood pressure and urine protein before and after treatment between the two groups were observed and compared.Result:The total effective rate of treatment group was 96.7%,it was significantly higher than 53.3% of control group,the differences were statistically significant(P<0.05).Compared with before treatment,the 24 hours urinary protein quantity after treatment of two groups were significantly reduced,and the 24 hours urinary protein quantity of treatment group was significantly lower than that of control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the urea nitrogen,serum creatinine and adverse reactions before and after treatment between two groups(P>0.05).Conclusion:Valsartan combined with low-dose Levamlodipine besylate in treatment of chronic glomerulonephritis has a good effect,with no serious adverse reactions,is worthy of clinical promotion.
