CAJ | 학술논문

目的：比较不同方案治疗术后腹膜后恶性淋巴结转移癌的临床疗效差异。方法：选取本院收治的58例消化道恶性肿瘤术后发生腹膜后恶性淋巴结转移癌的患者，分为对照组（FOLFOX4方案单纯化疗）和观察组（三维适形放疗同步FOLFOX4方案），比较两组肿瘤控制率、KPS评分、不良反应发生率和远期生存率的差异。结果：观察组肿瘤控制率为82.8%，显著高于对照组的62.1%，观察组KPS评分显著高于对照组，观察组累积生存率和平均生存期均显著高于对照组，比较差异有统计学意义（P<0.05）；两组患者不良反应发生率比较差异无统计学意义（P>0.05）。结论：三维适形放疗同步FOLFOX4方案治疗术后腹膜后恶性淋巴结转移癌效果确切，有利于肿瘤的控制，近远期疗效均好。
목적：비교불동방안치료술후복막후악성림파결전이암적림상료효차이。방법：선취본원수치적58례소화도악성종류술후발생복막후악성림파결전이암적환자，분위대조조（FOLFOX4방안단순화료）화관찰조（삼유괄형방료동보FOLFOX4방안），비교량조종류공제솔、KPS평분、불량반응발생솔화원기생존솔적차이。결과：관찰조종류공제솔위82.8%，현저고우대조조적62.1%，관찰조KPS평분현저고우대조조，관찰조루적생존솔화평균생존기균현저고우대조조，비교차이유통계학의의（P<0.05）；량조환자불량반응발생솔비교차이무통계학의의（P>0.05）。결론：삼유괄형방료동보FOLFOX4방안치료술후복막후악성림파결전이암효과학절，유리우종류적공제，근원기료효균호。
Objective:To compare clinical efficacy of different treatment for postoperative malignant retroperitoneal lymph node metastasis carcinoma. Method:58 cases with retroperitoneal lymph node metastases after resection of gastrointestinal cancer surgery in our hospital were randomly divided into control group(treated with FOLFOX4)and observation group(treated with three-dimensional conformal radiotherapy synchronous FOLFOX4). The tumor control rate,KPS score,adverse reactions rate and long-term survival rate of two groups were compared. Result:Tumor control rate of observation group was 82.8%,which was significantly higher than 62.1% of the control group (P<0.05). KPS score of observation group was significantly higher than that of the control group(P<0.05). Adverse reactions rate of the two groups had no significant difference(P>0.05). Cumulative survival rate and mean survival time of observation group were significantly higher than that of the control group(P<0.05). Conclusion:Three-dimensional conformal radiotherapy synchronous FOLFOX4 for postoperative malignant retroperitoneal lymph node metastasis carcinoma has exact effect with a high near-term effect. It’s conducive to tumor control.