CAJ | 학술논문

目的：探讨氨磺必利联合舍曲林对老年期抑郁症的治疗作用。方法采用随机开放对照研究，将符合《中国精神障碍分类与诊断标准(第3版)》(CCMD-3)的60例老年期抑郁症的患者随机分为研究组(氨磺必利联合舍曲林治疗组)与对照组(单纯舍曲林治疗组)，分别在治疗前及治疗后第2、4、6、8周末，采用汉密尔顿抑郁量表(HAMD)、临床总体印象量表(CGI-GI)评定疗效，采用Asberg抗抑郁剂副反应量表(SERS)评定两组的药物副反应。结果研究组HAMD评分在治疗后2周末、4周末、6周末以及8周末与治疗前比较差异有统计学意义( P<0.05或0.01)；研究组CGI-GI总评分在治疗4周末、6周末以及8周末与治疗前比较差异有统计学意义( P均<0.01)；治疗后第4、6、8周末，研究组CGI-GI总评分与对照组比较差异有统计学意义(P<0.05或0.01)；对照组CGI-GI总评分在治疗8周末与治疗前比较差异有统计学意义(P<0.01)。治疗后第8周末，对照组SERS评分与研究组比较[(5.4±2.8)分vs.(4.7±2.6)分]，差异无统计学意义(P>0.05)。结论氨磺必利联合舍曲林对老年期抑郁症的疗效优于单一应用舍曲林治疗，安全性好。
목적：탐토안광필리연합사곡림대노년기억욱증적치료작용。방법채용수궤개방대조연구，장부합《중국정신장애분류여진단표준(제3판)》(CCMD-3)적60례노년기억욱증적환자수궤분위연구조(안광필리연합사곡림치료조)여대조조(단순사곡림치료조)，분별재치료전급치료후제2、4、6、8주말，채용한밀이돈억욱량표(HAMD)、림상총체인상량표(CGI-GI)평정료효，채용Asberg항억욱제부반응량표(SERS)평정량조적약물부반응。결과연구조HAMD평분재치료후2주말、4주말、6주말이급8주말여치료전비교차이유통계학의의( P<0.05혹0.01)；연구조CGI-GI총평분재치료4주말、6주말이급8주말여치료전비교차이유통계학의의( P균<0.01)；치료후제4、6、8주말，연구조CGI-GI총평분여대조조비교차이유통계학의의(P<0.05혹0.01)；대조조CGI-GI총평분재치료8주말여치료전비교차이유통계학의의(P<0.01)。치료후제8주말，대조조SERS평분여연구조비교[(5.4±2.8)분vs.(4.7±2.6)분]，차이무통계학의의(P>0.05)。결론안광필리연합사곡림대노년기억욱증적료효우우단일응용사곡림치료，안전성호。
Objective To study treatment effect of low dose Amisulpride combined Sertraline in the elderly depression. Meth-ods Employed open label extension study to randomized controlled trial, 60 patients ( no less than 60 years old) met with CCMD-3 for Depression criteria were divided into research group (treated with ow dose Amisulpride combined Sertraline ,n=30) and control group (treated with Sertraline,n=30) randomly. All subjects were assessed with Hamilton Rating Scale for Depression(HAMD),Clin-ical Global Impression(CGI-GI),Asberg Rating Scale for Side Effects before treatment and after 2,4,6 and 8 week treatment. Resu-lts There is significant HAMD difference between before treatment and after 2,4,6 and 8 week treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between before treatment and after 4,6 and 8 weeks treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between control group and after 4,6 and 8 weeks treatment in research group(P<0. 05 or 0. 01). There is significant CGI-GI difference between before and after 8 weeks treatment in control group(P<0. 01). There was no significant difference of score of Asberg Rating Scale for Side Effects between two groups(P>0. 05). Conclusion Treatment with low dose Amisulpride combined Sertraline for depression in the elderly is safe and treatment effect is better than that of Sertraline.