四川精神卫生
四川精神衛生
사천정신위생
SICHUAN MENTAL HEALTH
2014年
5期
385-389
,共5页
陈静%夏光源%汤稳权%魏华%邹涛
陳靜%夏光源%湯穩權%魏華%鄒濤
진정%하광원%탕은권%위화%추도
雌二醇(E2)%孕酮(P)%5-羟色胺(5-HT)%产后抑郁
雌二醇(E2)%孕酮(P)%5-羥色胺(5-HT)%產後抑鬱
자이순(E2)%잉동(P)%5-간색알(5-HT)%산후억욱
Estradiol (E2)%Progesterone (P)%Serotonin (5-HT)%Postpartum depression
目的：探讨分娩前后一周的血清雌二醇( E2)、孕酮( P)对产后抑郁的影响。方法选取2012年3月-2012年9月在贵阳医学院附属医院就诊的395例孕产妇为研究对象,采用爱丁堡产后抑郁量表( EPDS)对其产后抑郁情况进行评定,并用采用生物素双抗体夹心酶联免疫吸附法( ELISA)测定产妇血清雌二醇( E2)、孕酮( P)、五羟色胺(5-HT)水平。结果①产后一周抑郁症状检出人数为48例,检出率为12.15%。②抑郁组与非抑郁组产后血清雌孕激素水平差异有统计学意义(P<0.05)。③相关分析显示：产后EPDS得分与产前血清雌二醇水平、产前产后血清孕酮水平及产后孕酮、雌二醇下降幅度呈正相关、与产后5-HT、雌二醇水平呈负相关( r=-0.881~0.920,P<0.01)。结论分娩后产妇的血清雌孕激素水平下降,产妇雌孕激素下降过快可能是导致产后抑郁发病的生物学因素之一。
目的：探討分娩前後一週的血清雌二醇( E2)、孕酮( P)對產後抑鬱的影響。方法選取2012年3月-2012年9月在貴暘醫學院附屬醫院就診的395例孕產婦為研究對象,採用愛丁堡產後抑鬱量錶( EPDS)對其產後抑鬱情況進行評定,併用採用生物素雙抗體夾心酶聯免疫吸附法( ELISA)測定產婦血清雌二醇( E2)、孕酮( P)、五羥色胺(5-HT)水平。結果①產後一週抑鬱癥狀檢齣人數為48例,檢齣率為12.15%。②抑鬱組與非抑鬱組產後血清雌孕激素水平差異有統計學意義(P<0.05)。③相關分析顯示：產後EPDS得分與產前血清雌二醇水平、產前產後血清孕酮水平及產後孕酮、雌二醇下降幅度呈正相關、與產後5-HT、雌二醇水平呈負相關( r=-0.881~0.920,P<0.01)。結論分娩後產婦的血清雌孕激素水平下降,產婦雌孕激素下降過快可能是導緻產後抑鬱髮病的生物學因素之一。
목적：탐토분면전후일주적혈청자이순( E2)、잉동( P)대산후억욱적영향。방법선취2012년3월-2012년9월재귀양의학원부속의원취진적395례잉산부위연구대상,채용애정보산후억욱량표( EPDS)대기산후억욱정황진행평정,병용채용생물소쌍항체협심매련면역흡부법( ELISA)측정산부혈청자이순( E2)、잉동( P)、오간색알(5-HT)수평。결과①산후일주억욱증상검출인수위48례,검출솔위12.15%。②억욱조여비억욱조산후혈청자잉격소수평차이유통계학의의(P<0.05)。③상관분석현시：산후EPDS득분여산전혈청자이순수평、산전산후혈청잉동수평급산후잉동、자이순하강폭도정정상관、여산후5-HT、자이순수평정부상관( r=-0.881~0.920,P<0.01)。결론분면후산부적혈청자잉격소수평하강,산부자잉격소하강과쾌가능시도치산후억욱발병적생물학인소지일。
Objective To explore the impact of serum estradiol ( E2 ) , progesterone ( P) on the postpartum depression about a week before and after childbirth. Methods Selection 395 cases of maternal who saw a doctor in guiyang medical college affiliated hos-pital as the research object in March 2012 - September 2012, using the Edinburgh postnatal depression scale ( EPDS) to assess the postpartum depression, and uses the biotin method of double antibody sandwich enzyme-linked immunosorbent ( ELISA) determina-tion of maternal serum estradiol (E2), progesterone (P), serotonin (5-HT) level. Results ①Depression detected the number of 48 cases, detection rate of 12. 15% a week after childbirth. ②Female serum progesterone level difference after childbirth between de-pression with and without depression group was statistically significant (P<0. 05). ③The correlation analysis showed that the postpartum EPDS scores and prenatal serum estradiol level, prenatal postpartum serum progesterone level and postnatal progesterone, estradiol de-clines were positively correlated, and negatively correlated with postpartum 5-HT, estradiol levels (r= -0. 881~0. 881,P<0. 01).Conclusion Maternal serum progesterone, estradiol level declined obviously after delivery, female progesterone and estradiol dramatic drops were important biological factors on postpartum depression.
