CAJ | 학술논문

目的：探讨血清同型半胱氨酸（Hcy）、巨噬细胞移动抑制因子（MIF）水平与颈动脉粥样硬化关系。方法对162例住院和门诊的受试者，应用多普勒彩超检测颈动脉内中膜厚度（IMT）及其斑块性质，根据超声检测结果分为3组：颈动脉IMT正常组32例，颈动脉IMT增厚组39例，颈动脉斑块组91例。对各组受试者分别测定血清Hcy、MIF水平及相关生化指标。对斑块组分为：稳定斑块亚组34例和不稳定斑块亚组57例。分析3组组间血清Hcy水平与IMF水平的差异，以及稳定斑块亚组及不稳定斑块亚组血清Hcy、MIF水平的差异，并分析Hcy、MIF与IMT的相关性。结果与IMT正常组比较，IMT增厚组、斑块组血清Hcy、MIF均明显较高，各组间比较差异有统计学意义（P＜0.05），且斑块形成组血清Hcy、MIF亦明显高于IMT增厚组（P＜0.05）；与稳定斑块亚组比较，不稳定斑块亚组血清Hcy、MIF水平明显高于稳定斑块亚组，差异有统计学意义（P＜0.05），Hcy、IMF与IMT有显著的相关性，相关系数分别为：0.558，0.604，P均＜0.05。结论血清Hcy、MIF水平可能与颈动脉粥样硬化的发生发展有关；血清Hcy、MIF水平升高可能导致颈动脉斑块的不稳定。
목적：탐토혈청동형반광안산（Hcy）、거서세포이동억제인자（MIF）수평여경동맥죽양경화관계。방법대162례주원화문진적수시자，응용다보륵채초검측경동맥내중막후도（IMT）급기반괴성질，근거초성검측결과분위3조：경동맥IMT정상조32례，경동맥IMT증후조39례，경동맥반괴조91례。대각조수시자분별측정혈청Hcy、MIF수평급상관생화지표。대반괴조분위：은정반괴아조34례화불은정반괴아조57례。분석3조조간혈청Hcy수평여IMF수평적차이，이급은정반괴아조급불은정반괴아조혈청Hcy、MIF수평적차이，병분석Hcy、MIF여IMT적상관성。결과여IMT정상조비교，IMT증후조、반괴조혈청Hcy、MIF균명현교고，각조간비교차이유통계학의의（P＜0.05），차반괴형성조혈청Hcy、MIF역명현고우IMT증후조（P＜0.05）；여은정반괴아조비교，불은정반괴아조혈청Hcy、MIF수평명현고우은정반괴아조，차이유통계학의의（P＜0.05），Hcy、IMF여IMT유현저적상관성，상관계수분별위：0.558，0.604，P균＜0.05。결론혈청Hcy、MIF수평가능여경동맥죽양경화적발생발전유관；혈청Hcy、MIF수평승고가능도치경동맥반괴적불은정。
Objective To discuss the relationship between homocysterine (Hcy) or macrophage migration inhibitory factor (MIF) and carotid artery atherosclerosis. Methods The patients (n=162) chosen from inpatient and outpatient departments were given detection of carotid artery intima-media thickness (CA-IMT) and plaque characters by using color Doppler ultrasonography, and then divided, according to ultrasonic outcomes, into normal group (n=32), thickening group (n=39) and plaque group (n=91). The levels of serum Hcy and MIF and related biochemical indexes were detected in all groups. The plaque group was further divided into stable subgroup (n=34) and unstable subgroup (n=57). The differences in levels of serum Hcy and MIF among 3 groups and between stable subgroup and unstable subgroup were compared, and correlation between Hcy or MIF and CA-IMT was analyzed. Results Compared with normal group, the levels of serum Hcy and MIF increased significantly in thickening group and plaque group (P<0.05), and higher in plaque group than those in thickening group (P<0.05). Compared with stable subgroup, the levels of serum Hcy and MIF increased significantly in unstable subgroup (P<0.05). Hcy and MIF were significantly correlated to CA-IMT (r=0.558, r=0.604, all P<0.05). Conclusion The levels of serum Hcy and MIF may related to the development of carotid artery atherosclerosis, and the increases of Hcy and MIF may induce unstable carotid plaque.