CAJ | 학술논문

目的：探讨CT联合血清指标等多元指标在不同组织分化程度肝细胞肝癌（hepatocelluar carcinoma ，HCC）行肝动脉灌注化疗栓塞术（transcatheter arterial chemo embolization ，TACE）后疗效评价中的价值。方法收集175例肝细胞肝癌TA‐CE首次介入治疗前及治疗后4～6周的临床资料，包括CT效果情况的判定、血清甲胎蛋白（AFP）、肝功能等，所有患者均经穿刺活检或手术切除病理确诊为肝癌。结果单因素分析结果显示，Child‐Pugh分级、肝功能、AFP浓度、组织学分级是影响HCC患者疗效的因素；不同组织分化程度 HCC介入治疗临床疗效差异有统计学意义，本组研究中高分化、中分化、低分化肝癌患者有效率分别为69.1、72.5、76.8％，低分化肝癌患者介入治疗的效果更好。结论 T ACE对低分化 HCC患者介入治疗有更好的临床疗效，Child‐Pugh分级、肝功能、AFP浓度是影响HCC患者疗效的因素。
목적：탐토CT연합혈청지표등다원지표재불동조직분화정도간세포간암（hepatocelluar carcinoma ，HCC）행간동맥관주화료전새술（transcatheter arterial chemo embolization ，TACE）후료효평개중적개치。방법수집175례간세포간암TA‐CE수차개입치료전급치료후4～6주적림상자료，포괄CT효과정황적판정、혈청갑태단백（AFP）、간공능등，소유환자균경천자활검혹수술절제병리학진위간암。결과단인소분석결과현시，Child‐Pugh분급、간공능、AFP농도、조직학분급시영향HCC환자료효적인소；불동조직분화정도 HCC개입치료림상료효차이유통계학의의，본조연구중고분화、중분화、저분화간암환자유효솔분별위69.1、72.5、76.8％，저분화간암환자개입치료적효과경호。결론 T ACE대저분화 HCC환자개입치료유경호적림상료효，Child‐Pugh분급、간공능、AFP농도시영향HCC환자료효적인소。
Objective To explore evaluation of curative effect on from the combination CT with serum indexes such as diversi‐ty index in different tissue differentiation degree of hepatocellular carcinoma (HCC) that have already accepted the hepatic arte‐rial infusion transcatheter arterial chemo embolization (TACE) .Methods 175 cases of HCC with conventional first before in‐terventional therapy and the clinical data of 4 to 6 weeks after treatment were collected ,including CT effect of judgement ,serum AFP ,liver function and so on ,all of the patients were pathological diagnased as liver cancer after biopsy or surgical removal .Re‐sults According to the results of single factor analysis ,Child‐Pugh grading ,liver function ,AFP concentration ,histological grad‐ing were factors influencing the curative effect of HCC patients .And the clinical curative effect of interventional treatment from different tissue differentiation degree of HCC had different statistically significant ,The efficient of different differentiation of liver cancer patients such as high ,medium and low efficient were 69.1 ,72.5 ,76.8% with respectively ,and low differentiation of liver cancer patients with interventional therapy effect was better .Conclusions TACE in patients with poorly differentiated HCC with conventional had better clinical curative effect ,and the Child‐Pugh grading ,liver function ,AFP concentration were factors influencing the curative effect of HCC patients .