CAJ | 학술논문

血管内皮细胞是血管的核心，表达一些特异性标志物如血管内皮生长因子受体2（VEGFR2）、CD31和血浆血管性血友病因子等，具有在基质胶上形成管状结构的特征。牙髓干细胞是具有自我更新能力和多向分化潜能的一类成体间质干细胞，在添加不同成分诱导物的条件培养基中可定向分化为成骨细胞、脂肪细胞、软骨细胞和神经细胞。体外研究发现，在添加血管内皮生长因子、成纤维细胞生长因子成分的低血清培养基培养一段时期后，牙髓干细胞可以表达内皮细胞标志物，同时具有形成血管状结构能力；体内研究发现，牙髓干细胞可促进低血区域组织血管生成和血流灌注，进一步证实牙髓干细胞亦可定向分化为内皮细胞。
혈관내피세포시혈관적핵심，표체일사특이성표지물여혈관내피생장인자수체2（VEGFR2）、CD31화혈장혈관성혈우병인자등，구유재기질효상형성관상결구적특정。아수간세포시구유자아경신능력화다향분화잠능적일류성체간질간세포，재첨가불동성분유도물적조건배양기중가정향분화위성골세포、지방세포、연골세포화신경세포。체외연구발현，재첨가혈관내피생장인자、성섬유세포생장인자성분적저혈청배양기배양일단시기후，아수간세포가이표체내피세포표지물，동시구유형성혈관상결구능력；체내연구발현，아수간세포가촉진저혈구역조직혈관생성화혈류관주，진일보증실아수간세포역가정향분화위내피세포。
Vascular?endothelial?cells?are?the?core?of?the?vessels.?These?cells?express?some?specific?markers,?such?as?vascular?endothelial?growth?factor?receptor2,?CD31,?and?the?von?Willebrand?factor.?These?cells?can?promote?the?formation?of?tube?structures?in?matrigel.?Dental?pulp?stem?cells?has?potential?for?self-renewal?and?differentiation?into?a?variety?of?cell?types,?including?osteoblast-like?cells,?chondrocytes,?adipocytes,?and?neural-like?cells?in?different?medium?with?various?content?of?inducer.?Dental?pulp?stem?cells?also?express?endothelial?cell?markers?and?form?vascular-like?structure?in vitro?when?cultured?in?low-serum?culture?medium?added?with?vascular?endothelial?growth?factor?and?fibroblast?growth?factor.?In vivo?studies?suggest?that?these?cells?can?promote?angiogenesis?and?blood?perfusion?of?regional?ischemic?tissue,?which?further?confirms?that?dental?pulp?stem?cells?can?also?be?differentiated?into?endothelial?cells.