CAJ | 학술논문

目的：探讨乳腺癌中TS，MRP，Topo的表达及临床意义。方法选择2010年5月～2013年6月在本院接受手术治疗并通过病理确诊乳腺癌的患者88例，乳腺纤维瘤患者15例，以及癌旁组织10例，通过免疫组化中的SP法染色，测定后结合临床后对其进行分析。结果癌旁正常组织内，经检测几乎未发现TS、MPR及Topo－Ⅱ的阳性表达；基于TS、MRP以及Topo－Ⅱ表达阳性率，乳腺癌组织明显高于乳腺纤维瘤组织，其中乳腺癌组织TS阳性表达率（42．05％，37／88）与乳腺纤维瘤组织阳性表达率（4．54％，4／88）之间的差异比较显著（P＜0．01），而二者的Topo－Ⅱ阳性表达率差异不明显（P＞0．05）。结论 TS，MRP，Topo在乳腺癌组织中的表达对选择各种化疗药物而言，具有相当重要的临床治疗意义。
목적：탐토유선암중TS，MRP，Topo적표체급림상의의。방법선택2010년5월～2013년6월재본원접수수술치료병통과병리학진유선암적환자88례，유선섬유류환자15례，이급암방조직10례，통과면역조화중적SP법염색，측정후결합림상후대기진행분석。결과암방정상조직내，경검측궤호미발현TS、MPR급Topo－Ⅱ적양성표체；기우TS、MRP이급Topo－Ⅱ표체양성솔，유선암조직명현고우유선섬유류조직，기중유선암조직TS양성표체솔（42．05％，37／88）여유선섬유류조직양성표체솔（4．54％，4／88）지간적차이비교현저（P＜0．01），이이자적Topo－Ⅱ양성표체솔차이불명현（P＞0．05）。결론 TS，MRP，Topo재유선암조직중적표체대선택각충화료약물이언，구유상당중요적림상치료의의。
Objective to study the TS in breast cancer,MRP,Topo expression and clinical significance. Methods in May 201 0 -June 201 3 in our hospital in patients undergoing surgery and pathological diagnosis of breast cancer in 88 cases,1 5 patients with mammary gland fibroma,tissue adjacent to carci-noma and 1 0 cases,by immunohistochemical SP method in dyeing,combined with clinical after determination to analyze it. Results in normal tissue adjacent to carcinoma,tested almost not found TS,MPR and Topo -Ⅱpositive expression;Based on TS,MRP and Topo -Ⅱexpression positive rate,breast cancer is significantly higher than the mammary gland fibroma,including breast cancer tissue TS positive expression rate (42. 05%,37/88)and mammary gland fibroma organization positive expression rate (4. 54%,4/88)is significant difference between the (P<0. 01 ),while the Topo -Ⅱpositive expression rate difference is not obvious (P>0. 05). Conclusion TS,MRP,Topo expression in breast cancer organizations to choose all kinds of chemotherapy drugs has important clinical significance.