牙体牙髓牙周病学杂志
牙體牙髓牙週病學雜誌
아체아수아주병학잡지
CHINESE JOURNAL OF CONSERVATIVE DENTISTRY
2014年
10期
602-605
,共4页
药物性牙龈增生%钙离子拮抗剂(CCB)%患病率%危险因素
藥物性牙齦增生%鈣離子拮抗劑(CCB)%患病率%危險因素
약물성아간증생%개리자길항제(CCB)%환병솔%위험인소
drug-induced gingival hyperplasia%calcium channel blockers(CCB)%prevalence%risk factors
目的：探讨高血压患者服用钙离子拮抗剂后出现牙龈增生的患病率。方法：对我院查体中心和心血管内科门诊服用钙离子拮抗剂抗高血压类药物的262和未服用钙离子拮抗剂的197例患者进行横断面调查。方法包括问卷调查和口腔牙周检查，其中牙龈增生的判定以牙龈增生指数（HI ）为诊断标准。对调查结果进行统计学分析。结果：服用钙离子拮抗剂类药物患者的牙龈增生患病率为20．23％，显著高于对照组的2．54％（χ2＝32．276，P＜0．05）。随年龄增大，药物性牙龈增生的患病率降低（r＝－0．155，P＜0．05）；单一用药者较联合用药者患病率高；服药时间越长患病率降低；随服药剂量的增加，患病率明显增长；口腔卫生状况差者可加重牙龈增生程度。结论：药物性牙龈增生是多方面作用的结果，其主要影响因素为患者年龄、服药方式、剂量、时间和牙周局部因素。
目的：探討高血壓患者服用鈣離子拮抗劑後齣現牙齦增生的患病率。方法：對我院查體中心和心血管內科門診服用鈣離子拮抗劑抗高血壓類藥物的262和未服用鈣離子拮抗劑的197例患者進行橫斷麵調查。方法包括問捲調查和口腔牙週檢查，其中牙齦增生的判定以牙齦增生指數（HI ）為診斷標準。對調查結果進行統計學分析。結果：服用鈣離子拮抗劑類藥物患者的牙齦增生患病率為20．23％，顯著高于對照組的2．54％（χ2＝32．276，P＜0．05）。隨年齡增大，藥物性牙齦增生的患病率降低（r＝－0．155，P＜0．05）；單一用藥者較聯閤用藥者患病率高；服藥時間越長患病率降低；隨服藥劑量的增加，患病率明顯增長；口腔衛生狀況差者可加重牙齦增生程度。結論：藥物性牙齦增生是多方麵作用的結果，其主要影響因素為患者年齡、服藥方式、劑量、時間和牙週跼部因素。
목적：탐토고혈압환자복용개리자길항제후출현아간증생적환병솔。방법：대아원사체중심화심혈관내과문진복용개리자길항제항고혈압류약물적262화미복용개리자길항제적197례환자진행횡단면조사。방법포괄문권조사화구강아주검사，기중아간증생적판정이아간증생지수（HI ）위진단표준。대조사결과진행통계학분석。결과：복용개리자길항제류약물환자적아간증생환병솔위20．23％，현저고우대조조적2．54％（χ2＝32．276，P＜0．05）。수년령증대，약물성아간증생적환병솔강저（r＝－0．155，P＜0．05）；단일용약자교연합용약자환병솔고；복약시간월장환병솔강저；수복약제량적증가，환병솔명현증장；구강위생상황차자가가중아간증생정도。결론：약물성아간증생시다방면작용적결과，기주요영향인소위환자년령、복약방식、제량、시간화아주국부인소。
AIM:To explore the relationship between calcium channel blockers and gingival hyperplasia. METHODS:459 subjects with high blood pressure were included.262 of them taking calcium channel blockers (CCB)were in CCB group,197 without use of CCB were in control group.All the subjects were investigated by a questionnaire and oral examination.Gingiva hyperplasia was assessed according to the diagnostic criteria of periodontal hperplasia index(HI).RESULTS:Gingival overgrowth was found in 20.23% of the subjects in CCB group and in 2.54% in control group(χ2 =32.276,P<0.05).Single factor analysis showed that age,dosage and duration of the drug use were the risk factors of gingival hyperplasia (P<0.05).There was a negative correlation between prevalence rate of gingival hyperplasia and the age of patients who took CCB(r=-0.155,P=0.012).There is close relationship between gingival overgrowth and periodontal local factors.CONCLUSION:The gingival hyperplasia is associated with the factors of CCB age,duration,administration method ,dosage of CCB and oral hygiene.
