CAJ | 학술논문

目的：探讨手足口病(HFMD)患儿血清白蛋白水平的变化及其与预后的相关性。方法选择2011年和2013年收治的HFMD患儿122例，其中普通型组57例、重型组52例、危重型组13例，比较三组患儿入院24 h内血清白蛋白、血糖、外周血白细胞计数，以及低白蛋白血症的发生概率和病死率。结果危重型组患儿血清白蛋白水平显著低于重型组和普通型组，血糖和外周血白细胞计数显著高于重型组和普通型组，差异有统计学意义(P均<0.05)，重型组和普通型组之间，上述指标的差异均无统计学意义(P均>0.05)。重型组和普通型组均无低白蛋白血症发生和死亡病例，危重型组患儿低白蛋白血症发生概率和病死率大于重型组和普通型组(P均<0.01)。结论危重型HFMD患儿病死率极高，血清白蛋白水平降低是危重型HFMD患儿死亡的高危因素，及早地动态监测血清白蛋白水平有助于预测HFMD患儿的病情和预后。
목적：탐토수족구병(HFMD)환인혈청백단백수평적변화급기여예후적상관성。방법선택2011년화2013년수치적HFMD환인122례，기중보통형조57례、중형조52례、위중형조13례，비교삼조환인입원24 h내혈청백단백、혈당、외주혈백세포계수，이급저백단백혈증적발생개솔화병사솔。결과위중형조환인혈청백단백수평현저저우중형조화보통형조，혈당화외주혈백세포계수현저고우중형조화보통형조，차이유통계학의의(P균<0.05)，중형조화보통형조지간，상술지표적차이균무통계학의의(P균>0.05)。중형조화보통형조균무저백단백혈증발생화사망병례，위중형조환인저백단백혈증발생개솔화병사솔대우중형조화보통형조(P균<0.01)。결론위중형HFMD환인병사솔겁고，혈청백단백수평강저시위중형HFMD환인사망적고위인소，급조지동태감측혈청백단백수평유조우예측HFMD환인적병정화예후。
Objective To observe levels of the serum albumin and their association with prognosis in children with hand-foot-and-mouth disease (HFMD) . Methods A total of 122 HFMD children admitted from 2011 to 2013 were selected and divided into three groups:common group (n=57), severe group (n=52) and critical group (n=13). Serum albumin levels, blood glucose levels, peripheral blood white cell counts of the children in the three groups were compared within 24 hours of admis-sion. Moreover, the incidence of hypoalbuminemia and mortality of the children were analyzed in each group. Results In critical group, serum albumin levels were signiifcantly decreased while blood glucose levels and peripheral blood white cell counts were signiifcantly increased than those in the severe group and common group, and the differences were all statistically signiifcant (all P<0.05). There were no signiifcant differences in serum albumin levels, blood glucose levels and peripheral blood white cell counts between severe group and common group (all P>0.05). There was no hypoalbuminemia and death in severe group and common group. The percentage of hypoalbuminemia and mortality of children in critical group were higher than those in the other two groups (all P<0.01). Conclusions The mortality was extremely high in children with critical HFMD. The decrease of serum albumin levels was a high risk factor for death in children with critical HFMD. Early and dynamic monitoring serum albu-min levels may be helpful in evaluation of disease condition and prognosis of HFMD.