CAJ | 학술논문

目的：探讨抗生素和手卫生规范管理对防控新生儿碳青霉烯类耐药肠杆菌科细菌(CRE)感染的意义。方法根据医院抗菌药物专项整治情况，将2011年1月至2013年12月划分为整治前期、过渡期以及整治后期，对同期新生儿病房抗生素使用强度、医务人员手卫生依从率、CRE检出率以及院内感染百分率等指标进行回顾性分析。结果抗生素使用强度从12.93 DDDs降至8.10 DDDs，医务人员手卫生依从率从53.49%升至83.33%，肠杆菌科细菌CRE检出率由3.71%降至2.27%，差异有统计学意义(P均<0.01)；院内CRE感染率由0.22%降至0.17%，但未达统计学意义(P=0.441)。结论合理应用抗生素、推行手卫生可作为经济有效的新生儿CRE感染防治措施。
목적：탐토항생소화수위생규범관리대방공신생인탄청매희류내약장간균과세균(CRE)감염적의의。방법근거의원항균약물전항정치정황，장2011년1월지2013년12월화분위정치전기、과도기이급정치후기，대동기신생인병방항생소사용강도、의무인원수위생의종솔、CRE검출솔이급원내감염백분솔등지표진행회고성분석。결과항생소사용강도종12.93 DDDs강지8.10 DDDs，의무인원수위생의종솔종53.49%승지83.33%，장간균과세균CRE검출솔유3.71%강지2.27%，차이유통계학의의(P균<0.01)；원내CRE감염솔유0.22%강지0.17%，단미체통계학의의(P=0.441)。결론합리응용항생소、추행수위생가작위경제유효적신생인CRE감염방치조시。
Objective To investigate the effect of standardized usage of antibiotics and hand hygiene on carbapenem-re-sistant Enterobacteriaceae (CRE) infection in neonates. Methods According to the situation of standardized management of an-tibiotics in our hospital, the study period, from January 2011 to December 2013, was divided into pre-intervention, transition and post-intervention. Retrospective study was employed to analyze the antibiotics use density (AUD), the hand hygiene compliance rate among the medical staff, the positive rate of CRE and the nosocomial infection percentage of the neonatology department. Results From pre-intervention to post-intervention period, the AUD was decreased from 12.93 DDDs to 8.10 DDDs;hand hy-giene compliance rate of medical staff was increased from 53.49%to 83.33%;the detection rate of CRE was decreased from 3.71%to 2.27%. The differences were all signiifcant among different periods (P<0.01). The nosocomial infection percentage decreased from 0.22%to 0.17%and there was no signiifcant difference (P=0.441). Conclusions Standardized usage of antibiotics and hand hygiene can be served as economical yet effective approaches to controlling CRE infection in neonates.