CAJ | 학술논문

目的：探讨急性传染性淋巴细胞增多症(AIL)患儿外周血共刺激分子4-1BB和淋巴细胞亚群的表达及意义。方法应用流式细胞术(FCM)检测和比较15例AIL患儿、20例急性上呼吸道感染(URI)患儿以及20例健康对照儿童的外周血4-1BB及淋巴细胞亚群的表达。结果 AIL患儿外周血4-1BB的表达及CD3+、CD4+、CD8+的表达均高于URI患儿及对照组，差异有统计学意义(P<0.05)；URI患儿与对照组间的差异则无统计学意义(P>0.05)。三组外周血CD19+CD23+的表达的差异无统计学意义(P>0.05)。AIL患儿外周血4-1BB的表达与CD3+的表达成显著正相关(r=0.73，P<0.05)。结论4-1BB可能参与了AIL的发病。AIL患儿异常增多的T细胞可能不具备活化B细胞的功能。
목적：탐토급성전염성림파세포증다증(AIL)환인외주혈공자격분자4-1BB화림파세포아군적표체급의의。방법응용류식세포술(FCM)검측화비교15례AIL환인、20례급성상호흡도감염(URI)환인이급20례건강대조인동적외주혈4-1BB급림파세포아군적표체。결과 AIL환인외주혈4-1BB적표체급CD3+、CD4+、CD8+적표체균고우URI환인급대조조，차이유통계학의의(P<0.05)；URI환인여대조조간적차이칙무통계학의의(P>0.05)。삼조외주혈CD19+CD23+적표체적차이무통계학의의(P>0.05)。AIL환인외주혈4-1BB적표체여CD3+적표체성현저정상관(r=0.73，P<0.05)。결론4-1BB가능삼여료AIL적발병。AIL환인이상증다적T세포가능불구비활화B세포적공능。
Objective To investigate expression of 4-1BB and lymphocyte subsets in peripheral blood of children with acute infectious lymphocytosis. Methods Flow cytometry (FCM) was applied to detect the expression of 4-1BB and lymphocyte subsets in peripheral blood of 15 cases of acute infectious lymphocytosis and 20 cases of acute upper respiratory infection, and 20 healthy children. Results The expression of 4-1BB and CD3+, CD4+and CD8+lymphocytes were higher in acute infectious lymphocytosis group than those in acute upper respiratory infection group and healthy control group (P<0.05). There was no sig-niifcant difference of CD19+CD23+lymphocytes among three groups (P>0.05). A positive correlation was found between 4-1BB expression and CD3+ lymphocytes expression in acute infectious lymphocytosis group (r=0.73, P<0.05). Conclusions The abnormal expression of 4-1BB may play a pathological role in the development of acute infectious lymphocytosis. T cells in chil-dren with acute infectious lymphocytosis may not function to activate B cells.