CAJ | 학술논문

目的：探讨过敏性紫癜(HSP)患儿外周血单个核细胞(PBMCs)中Th17细胞比例及血清IL-17水平变化的临床意义。方法选择HSP患儿30例和正常对照儿童20例，应用流式细胞分析法检测外周血Th17细胞的比例，应用ELISA法检测血清IL-17水平，分析和比较HSP患儿和对照儿童的检测结果。结果 HSP患儿PBMCs中Th17细胞比例为(2.14±0.90)%，显著高于对照组的(0.84±0.41)%，差异有统计学意义(P<0.05)；HSP患儿血清IL-17水平为(38.36±13.44)pg/ml，高于对照组的(10.59±4.17)pg/ml，差异有统计学意义(P<0.05)。结论 HSP患儿PBMC中Th17细胞比例明显增高，提示Th17细胞可能参与了HSP的发病过程。
목적：탐토과민성자전(HSP)환인외주혈단개핵세포(PBMCs)중Th17세포비례급혈청IL-17수평변화적림상의의。방법선택HSP환인30례화정상대조인동20례，응용류식세포분석법검측외주혈Th17세포적비례，응용ELISA법검측혈청IL-17수평，분석화비교HSP환인화대조인동적검측결과。결과 HSP환인PBMCs중Th17세포비례위(2.14±0.90)%，현저고우대조조적(0.84±0.41)%，차이유통계학의의(P<0.05)；HSP환인혈청IL-17수평위(38.36±13.44)pg/ml，고우대조조적(10.59±4.17)pg/ml，차이유통계학의의(P<0.05)。결론 HSP환인PBMC중Th17세포비례명현증고，제시Th17세포가능삼여료HSP적발병과정。
Objective To observe the percentage of Th17 cells in peripheral blood mononuclear cells (PBMCs) and the serum level of interleukin-17 (IL-17) in children with Henoch-Sch?nlein purpura (HSP). Methods A total of 30 HSP children and 20 healthy children were selected. The percentage of Th17 cells in PBMCs was measured by lfow cytometry analysis and the serum level of IL-17 was measured by ELISA method. The results were compared between HSP children and healthy children. Results The percentage of Th17 cells in PBMCs in HSP and healthy children was (2.14 ± 0.90)%and (0.84 ± 0.41)%, respec-tively, and the difference was signiifcant between two groups (P<0.05). The serum levels of IL-17 in HSP and healthy children were (38.36 ± 13.44) pg/ml and (10.59 ± 4.17) pg/ml, respectively, and the difference was also signiifcant (P<0.05). Conclusions The percentage of Th17 cells in PBMCs was obviously increased in HSP children. It is suggested that Th17 cells may play a role in the pathology of HSP.